Studying the Effect of Variables on Acyclovir Microsponge

Noor Y. Fareed; Hanan J. Kassab

doi:10.31351/vol27iss2pp66-76

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Publication Date

Thu Dec 06 2018

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

Volume

27

Issue Number

2

DOI

10.31351/vol27iss2pp66-76

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Studying the Effect of Variables on Acyclovir Microsponge

microsponge

Acyclovir

controlled topical release

oil in oil emulsion solvent diffusion

Noor Y. Fareed

Hanan J. Kassab

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The aim of the present investigation was to develop a microsponge delivery system of acyclovir to control its release when applied topically thereby reducing dosing frequency and enhancement patient compliance. The microsponges were produced by the oil in oil emulsion solvent diffusion method. The effect of different formulation and process variables such as internal phase volume, polymer type, drug-polymer ratio, stirring speed and stirring duration on microsponge production yield, loading efficiency, particle size and in-vitro drug release was evaluated. The result showed that the microsponge F2 prepared from Eudrajet RS polymer had optimum physical properties regarding the loading efficiency of 99.71_+ 0.7% and production yield which was 85%. Also, F2 showed 66% drug release within 8 hours. Accordingly, the oil in oil emulsion solvent diffusion method is an effective technique to formulate microsponges with maximum production yield and loading efficiency for acyclovir.

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Publication Date

Sun Jul 08 2018

Journal Name

Journal Of Global Pharma Technology

Association of Insulin-Like Growth Factor 2 Apa 1 A820G (rs680) Polymorphism with Thyroid Dysfunction in a Sample Iraqi Patien

Taghreed

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Publication Date

Tue Sep 01 2015

Journal Name

Photomedicine And Laser Surgery

Evaluation of Temperature Elevation During Root Canal Treatment with Dual Wavelength Laser: 2780 nm Er,Cr:YSGG and 940 nm Diode

Al-Karadaghi T.S.

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(34)

Publication Date

Thu Feb 16 2023

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

Cost-effectiveness Analysis of Reference Infliximab (Remicade) Compared to its Biosimilar (Remsima) in Iraqi Patients with Rheumatoid Arthritis (Conference Paper )#

Cost-effectiveness

Rheumatoid arthritis

Infliximab

Biosimilar

Biological medicine

Quality of life

Iraq

Pharmacoeconomics

Hasan Raid

Ali Azeez

Nizar Abdulateef

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The study objective was to conduct Pharmacoeconomics study (cost-effective analysis) between infliximab reference (Remicade) and its biosimilar (Remsima) in patients with rheumatoid arthritis (RA) in Iraqi hospitals.

This is a retrospective multicenter pharmacoeconomic analysis conducted at two large teaching governmental hospitals in Baghdad, Iraq which provided infliximab to patients with RA. Data were collected from patient’s medical records and face-to-face interviews with the patients from December 2021 to April 2022.

The study included 57 patients with rheumatoid arthritis (RA). The patients were categorized into two groups according to the type of infliximab they received over 30 weeks: 27 patients received

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(7)

(6)

Publication Date

Tue Jun 30 2020

Journal Name

Membranes

Experimental and Theoretical Analysis of Lead Pb2+ and Cd2+ Retention from a Single Salt Using a Hollow Fiber PES Membrane

Salwa

Ahmed A.

Sama M.

Mahmood F.

Hasan Shaker

Qusay F.

Khalid T.

Salah S.

Issam K.

Alberto

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The present work reports the performance of three types of polyethersulfone (PES) membrane in the removal of highly polluting and toxic lead Pb2+ and cadmium Cd2+ ions from a single salt. This study investigated the effect of operating variables, including pH, types of PES membrane, and feed concentration, on the separation process. The transport parameters and mass transfer coefficient (k) of the membranes were estimated using the combined film theory-solution-diffusion (CFSD), combined film theory-Spiegler-Kedem (CFSK), and combined film theory-finely-porous (CFFP) membrane transport models. Various parameters were used to estimate the enrichment factors, concentration polarization modulus, and Péclet number. The pH values signif

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(25)

Publication Date

Sun Mar 01 2020

Journal Name

Iop Conference Series: Materials Science And Engineering

Using spatial analysis techniques to Preparing maps for distribution of pollutant concentrations in Shatt al-Arab waters in November 2015

Z. F.

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AbstractWater has a great self-generating capacity that can neutralize the polluting interventions carried out by humans. However, if human activities continue this uncontrolled and unsustainable exploitation of this resource, this regenerating capacity shall fail and it will be jeopardized definitively. Shatt Al-Arab River in South of Iraq. It has an active role in providing water for irrigation, industry, domestic use and a commercial gateway to Iraq. in the last five years Shatt Al-Arab suffered from a rise in pollutants due to the severe decline in sewage networks, irregular networks and pesticide products, as well as the outputs of factories and companies that find their way to water sou ... Show More

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(5)

Publication Date

Mon Jul 01 2024

Journal Name

Journal Of Food Process Engineering

Artificial intelligence‐based modeling of novel non‐thermal milk pasteurization to achieve desirable color and predict quality parameters during storage

Ali Wali M.

Asaad R.

Azhar J.

Mohsen

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Abstract<sec><label></label>This study proposed using color components as artificial intelligence (AI) input to predict milk moisture and fat contents. In this sense, an adaptive neuro‐fuzzy inference system (ANFIS) was applied to milk processed by moderate electrical field‐based non‐thermal (NP) and conventional pasteurization (CP). The differences between predicted and experimental data were not significant (<italic>p</italic> > 0.05) for lightness (<italic>L</italic>*), redness‐greenness (<italic>a</italic>*), yellowness‐blueness (<italic>b</italic>*), total color differences (∆<italic>E</italic>), hue angle (<italic>h</italic></sec> ... Show More

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(4)

Publication Date

Fri Jul 01 2022

Journal Name

Operative Dentistry

Interfacial Bond Strength and Morphology of Sound and Caries-affected Dentin Surfaces Bonded to Two Resin-modified Glass Ionomer Cements

Resin modified Glass ionomer cement

Activa bioactive

Caries affected dentin

Shear bond strength

RM

LA

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SUMMARY<sec> <title>Objective

To evaluate the shear bond strength and interfacial morphology of sound and caries-affected dentin (CAD) bonded to two resin-modified glass ionomer cements (RMGICs) after 24 hours and two months of storage in simulated body fluid at 37°C.

Methods and Materials

Sixty-four permanent human mandibular first molars (32 sound and 32 with occlusal caries, following the International Caries Detection and Assessment System) were selected. Each prepared substrate (sound and CAD) was co

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(13)

Publication Date

Thu Nov 02 2023

Journal Name

Journal Of Engineering

Optimum Reinforcement Depth Ratio for Sandy Soil Enhancement to Support Ring Footing Subjected to a Combination of Inclined-Eccentric Load

Eccentric-inclined load

Ring footing

Reinforcement

Reinforcement depth ratio

Jumana Yousif Mohammed

A’amal A.H.

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This work investigates the impacts of eccentric-inclined load on ring footing performance resting on treated and untreated weak sandy soil, and due to the reduction in the footing carrying capacity due to the combinations of eccentrically-inclined load, the geogrid was used as reinforcement material. Ring radius ratio and reinforcement depth ratio parameters were investigated. Test outcomes showed that the carrying capacity of the footing decreases with the increment in the eccentric-inclined load and footing radius ratio. Furthermore, footing tilt and horizontal displacement increase with increasing the eccentricity and inclination angle, respectively. At the same time, the increment in the horizontal displacement due t

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Publication Date

Thu Jan 07 2021

Journal Name

Indian Journal Of Forensic Medicine & Toxicology

Assessment of Employees’ Knowledge Concerning Contributing Factors and Early Detection for Prostate Cancer in Baghdad University Colleges in bab-Almudam

Majeed

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(10)

(1)

Publication Date

Mon Nov 01 2021

Journal Name

Journal Of Physics: Conference Series

Neural Network Model for Synthesis of Thermally Sprayed (AI/AI2O3) Composite Protective Coatings

Thamir Abdul-Jabbar

Saad Ali

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AbstractAl2O3 and Al2O3–Al composite coatings were deposited on steel specimens using Oxy-acetylene gas thermal spray gun. Alumina was mixed with Aluminum in six groups of concentrations (0, 5, 10,12,15 and 20% ) Al2O3, Specimens were tested for corrosion using Potentiodynamic polarization technique. Further tests were conducted for the effect of temperature on polarization curve and the hardness tests for the coated specimens. At first, Modelling was carried out using MINITAB-19, least square method, as a 2nd degree nonlinear model, bad results were achieved because of the high nonlinearity. Better result w ... Show More

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