Enhancement of the Solubility and Dissolution Rate of Rebamipide   by Using Solid Dispersion Technique (Part I)

Muna Y. Ismail; Mowafaq M. Ghareeb

doi:10.31351/vol27iss2pp55-65

Details

Publication Date

Thu Dec 06 2018

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

Volume

27

Issue Number

2

DOI

10.31351/vol27iss2pp55-65

Choose Citation Style

Statistics

View publication

73

Abstract Views

1.76K

Galley Views

1.92K

Statistics

(19)

(7)

Enhancement of the Solubility and Dissolution Rate of Rebamipide by Using Solid Dispersion Technique (Part I)

rebamipide

solid dispersion

TPGS

Muna Y. Ismail

Mowafaq M. Ghareeb

...Show More Authors

Solid dispersion is an attractive tool of pharmaceutical technology used to improve the physical properties of drugs. Among these properties is to enhance the solubility of the drugs.
Rebamipide is a poorly soluble drug of class IV of biopharmaceutical classification system (BCS).
Rebamipide is used as potent antiulcer, mucoprotective drug, by stimulating the generation of prostoglandine enhanced mucosal protection.
Rebamipide was formulated as a solid dispersion using different polymers such as pluronic F-127, PEG6000, PVP K30, and TPGS by using different preparation methods solvent evaporation, fusion, and kneading methods.
It was seen that rebamipide was successfully dispersed in a homogenous solid dispersion matrix by solvent evaporation method using TPGS (1:15) drug carrier ratio.
Moreover, the results revealed that the solubility of rebamipide (23.9µg/ml) increased significantly (p?0.05) by 36.4 x fold to obtain 874µg/ml solubility in rebamipide matrix.
On the other hand, characterization of rebamipide solid dispersion using FTIR, DSC, SEM and x-ray diffraction demonstrated no drug polymer interaction, and converting the rebamipide from crystal to amorphous state lattice.

View Publication Preview PDF

Quick Preview PDF

Publication Date

Fri Mar 20 2020

Journal Name

Plant Archives (09725210) 20 (2)‏

Influence of some factor on somatic embryos induction and germination of date palm CV barhi by using cell suspension culture technique.‏

Moayad Rajab Abood

...Show More Authors

Publication Date

Mon Apr 06 2020

Journal Name

August

INFLUENCE OF SOME FACTOR ON SOMATIC EMBRYOS INDUCTION AND GERMINATION OF DATE PALM CV BARHI BY USING CELL SUSPENSION CULTURE TECHNIQUE

This study was done to examine different concentrations of mercuric chloride (Hgcl2) for Explants sterilization and different concentration of NAA) mg/L with 2iP for their effect on initiation primary callus and subsequent embryogenesis in Phoenix dactyliferae cultivar Barhi. Leaf primordial and shoot tips were excised from 2-3 years old offshoot. The result showed that contamination percentage decreased with an increase in concentration of Hgcl2 for two explants where in the control (0.0)% gave highest value 75% and 62.5% of contamination for leaf primordial and shoot tip respectively while the addition (0.1)% gave a significant decrease 37.5 and 0% for explants respectively. The Explants were inoculated onto Murashiege and Skoog

1962 (MS) medium supplemented with 2iP 3mg/L and containing 0

25

50 or 100 mg/L of NAA

the addition (50) mg/L of NAA gave highest value 68.8% in percentage of callus initiation with significant difference from addition 0% gave lowest value (18.8)%

as well Explants of shoot tip gave significant difference was 53.1% while leaf primordial gave 28.1%

Primary callus was transferred to fresh MS medium containing (0

5

10 and 20) mg/L of NAA with 3mg/L 2iP

Results were recorded after 12 weeks. A highest value of embryonic callus induction percentage or fresh weight and dry weight 87.5% or 1.56g and 0.47g for the character respectively for the treat 20 mg/L while control treatment 0.0 gave the lowest value 12.5% or 0.37g and 0.14g for same character respectively. Inoculated 1g fresh biomass into a 250 ml Erlenmeyer flask containing 50 ml MS liquid medium supplemented with NAA 20mg/L and agitated at 150 rpm by shaker to making suspension culture the measurements of packed cell volume ( pcv) or fresh and dry weight taken weekly for 12 weeks

maximum values were reached in the eighth week of PCV and fresh weight but the dry weight reached to highest value in seventh week

then the curve began to decline gradually until it reached stability in the last two weeks. The cell suspension was Diluted to different initial cell density of 100

500

10000

50000 and 100000 cells /ml with hemocytometer. The initial cell number of (10000) cells gave significant different of plating efficiency PE (11.6)% while (100) cells gave lowest value 1.8% of PE.

Ali A.

...Show More Authors

View Publication

Publication Date

Mon Nov 29 2021

Journal Name

Journal Of The Faculty Of Medicine Baghdad

The treatment of non complicated sacrococcygeal pilonidal sinus by minimal excision and primary closure technique

Pilonidal sinus

minimal excision

primary closure

recurrence rate.

Nabil I.

Tharwat I

...Show More Authors

Background: The surgical treatment of pilonidal sinus varies from wide excision and laying the wound open or excision with primary closure or excision with the use of skin graft in some special cases.
Objectives: The objectives of this study is to determine the efficacy of treating non complicated pilonidal sinus disease with minimal excision and primary closure technique, complications and recurrence rate.
Patients and methods: This is a prospective study conducted in shahid ahmed ismaiel hospital in rania – As sulaimania IRAQ during the period from December 2013 to January 2016 and was carried on one hundred (100) consecutive patients with non complicated non recurrent pilonidal sinus patients who were treated with minimal exci

View Publication Preview PDF

Publication Date

Sat Apr 01 2017

Journal Name

Image & Video Processing

Enhancement of LBP-based face identification system by adopting preprocessing techniques

Face Recognition

Enhancement

LBP

Raafat

Mohammed

...Show More Authors

Face Identification system is an active research area in these years. However, the accuracy and its dependency in real life systems are still questionable. Earlier research in face identification systems demonstrated that LBP based face recognition systems are preferred than others and give adequate accuracy. It is robust against illumination changes and considered as a high-speed algorithm. Performance metrics for such systems are calculated from time delay and accuracy. This paper introduces an improved face recognition system that is build using C++ programming language with the help of OpenCV library. Accuracy can be increased if a filter or combinations of filters are applied to the images. The accuracy increases from 95.5% (without ap

View Publication

Publication Date

Sat Sep 30 2017

Journal Name

Al-khwarizmi Engineering Journal

Thermal Conductivity Enhancement of Iraqi Origin Paraffin Wax by Nano-Alumina

Latent heat

Nano-alumina

Paraffin wax

Thermal storage

Miqdam T.

Rasha Mohammed

Aida Mohammed

...Show More Authors

Abstract

Paraffin wax is utilized for the heat storage applications taking advantage from the high stored latent heat during the phase change (from solid to fluid) period. What isn't right with this procedure is that the wax has a little heat transfer rate because of its low thermal conductivity. The thermal conductivity improvement of the paraffin wax has been examined utilizing nano-material with high thermal conductivity. In the recent study, (Al₂O₃) nanoparticles with weights of 1, 2, and 3% of the paraffin wax were added to the paraffin wax. The Iraqi paraffin wax accessible at the local markets was utilized as a phase change material (PCM).

Many properties of the

View Publication Preview PDF

(11)

Publication Date

Fri Nov 10 2023

Journal Name

Chalcogenide Letters

Enhancement efficiency of cadmium selenium solar cell by doping within silver

Mustafa M.H.

...Show More Authors

We studied at the morphology, structural setup, and optical characteristics of thin cadmium (CdSe) films a thickness of 250 nm that were created by thermal evaporation over glass, The films exhibited a hexagonal shape were crystalline, and tended to form grains in the (111) crystallographic direction, according to the X-ray diffraction examinations. These characteristics were established using the investigation's findings. Through the use of thin films of CdSe doped with Ag at a concentration of 1.5%, the crystal structure orientations for pure CdSe (25.32, 41.84) and CdSe:Ag (25.39, 41.01) that were both pure as well as those that were doped with silver were both determined. The band gap of the optical spectrum decreased by 1.93–

View Publication

(10)

(8)

Publication Date

Tue Oct 01 2013

Journal Name

Proceedings Of The International Astronomical Union

The infrared K-band identification of the DSO/G2 source from VLT and Keck data

A.

M.

S.

M.

K.

N.

B.

S.

L.

M.

A.

M.

G.

V.

M.

L.

R.

B.

M.

C.

D.

J.

C.

Y. E.

K.

A.

...Show More Authors

AbstractA fast moving infrared excess source (G2) which is widely interpreted as a core-less gas and dust cloud approaches Sagittarius A* (Sgr A*) on a presumably elliptical orbit. VLT <italic>Ks</italic>-band and Keck <italic>K</italic>′-band data result in clear continuum identifications and proper motions of this ∼19<italic>m</italic> Dusty S-cluster Object (DSO). In 2002-2007 it is confused with the star S63, but free of confusion again since 2007. Its near-infrared (NIR) colors and a comparison to other sources in the field speak in favor of the DSO being an IR excess star with photospheric continuum emission at 2 microns than a ... Show More

View Publication

(5)

(1)

Publication Date

Mon May 07 2018

Journal Name

Human And Ecological Risk Assessment: An International Journal

Multi-biomarker responses after exposure to organophosphates chlorpyrifos in the freshwater mussels Unio tigridis and snails Viviparous benglensis

Ali Abdulhamza

Adel M.

Ayad M. J.

...Show More Authors

View Publication

(22)

(20)

Publication Date

Tue Sep 01 2020

Journal Name

Baghdad Science Journal

Diversity and Geographical Distribution of Sand Flies Phlebotomus papatasi (Diptera: Phlebotominae) by using Geometric Morphometric Technique from two Iraqi Provinces

Diptera

Geometric Morphometric

Sand flies

Phlebotominae.

Sahar Abd

Riyadh

Soolaf A.

Nawras

...Show More Authors

The variation in wing morphological features was investigated using geometric morphometric technique of the Sand Fly from two Iraqi provinces Babylon and Diyala . We distributed eleven landmarks on the wings of Sand Fly species. By using the centroid size and shape together, all species were clearly distinguished. It is clear from these results that the wing analysis is an essential method for future geometric morphometry studies to distinguish the species of Sand Flies in Iraq.

View Publication Preview PDF

(1)

Publication Date

Thu Jul 01 2021

Journal Name

International Journal Of Nonlinear Analysis And Application

Forecasting enhancement using a hodrick-prescott filter

forecasting

Spectrum Analysis

Hodrick-Prescott Filter

Mohamed A.S.

Nooriya A.

...Show More Authors

: Sound forecasts are essential elements of planning, especially for dealing with seasonality, sudden changes in demand levels, strikes, large fluctuations in the economy, and price-cutting manoeuvres for competition. Forecasting can help decision maker to manage these problems by identifying which technologies are appropriate for their needs. The proposal forecasting model is utilized to extract the trend and cyclical component individually through developing the Hodrick–Prescott filter technique. Then, the fit models of these two real components are estimated to predict the future behaviour of electricity peak load. Accordingly, the optimal model obtained to fit the periodic component is estimated using spectrum analysis and Fourier mod

Preview PDF

(1)

1 2 ... 22 23 24 25 ... 3103 3104