Preferred Language
Articles
/
bijps-407
Guggulusome - A Novel Vesicular Carriers for Enhanced Transdermal Delivery
...Show More Authors

The present work describes guggul as a novel carrier for some anti-inflammatory drugs. Guggulusomes containing different concentration of guggul with aceclofenac were prepared by sonication method and characterized for vesicle shape, size, size-distribution, pH, viscosity, spread ability, homogeneity, and accelerated stability in-vitro drug permeation through mouse skin. The vesicles exhibited an entrapment efficiency of 93.2 ± 12%, vesicle size of 0.769 ± 3μm and a zeta potential of - 6.21mV. In vitro drug release was analyzed using Franz’s diffusion cells. The cumulative release of the guggulusomes gel (G2) was 75.8% in 18 hrs, which is greater than that all the gel formulation. The stability profile of prepared system assessed for 45 days. The vesicular suspension was kept in sealed vials (10ml) at 4 ± 2ºC and at room temperature for 45 days no change was showned in entrapment efficiency. The optimized guggulusomes formulation showed transdermal flux 216.1μg/cm²/hr. The result advocates the potential of guggulusomes formulation to treat diseases where facilitated penetration of the drug into muscle and synovial fluid is desirable. In the end of the tests guggulusomes gel G2 with carbopol 934K was the most stable. The paw edema and percentage inhibition of carrageenan-induced paw edema in rats treated with aceclofenac guggulusomes gels and commercial formulation of aceclofenac gel marketed gel. The formulation G2 were devoid of any irritation potential and no edema formation was observed in any case. Irritation score for aceclofenac guggulusomes gels was zero, which indicated its acceptability for topical administration.

Keywords:  Aceclofenac, Gel, Carbopol, Guggulu carrier.

Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Wed Mar 30 2022
Journal Name
Nasaq Journal
Lingual Sovereignty: Chinua Achebe’s Novel Things Fall Apart A Postcolonial Study
...Show More Authors

The discourse surrounding lingual sovereignty within the African postcolonial context is profoundly intertwined with the fabric of cultural identity and self-determination. Language serves not merely as a conduit for communication but as a repository for a people's collective consciousness, encapsulating their traditions, thoughts, and perspectives. In the realm of postcolonial literature, this dialogue often grapples with the paradox of expressing indigenous narratives through the linguistic tools of former colonizers. Chinua Achebe's seminal work, "Things Fall Apart," exemplifies this conundrum, artfully weaving the orature and culture of Umuofia within the English language. Achebe's choice to write in English—a language imposed upon hi

... Show More
View Publication Preview PDF
Publication Date
Thu Dec 19 2024
Journal Name
Ieee Explorer
A Novel Flow Priority and Continuity Control Mechanism in SDN Network
...Show More Authors

In recent days, the escalating need to seamlessly transfer data traffic without discontinuities across the Internet network has exerted immense pressure on the capacity of these networks. Consequently, this surge in demand has resulted in the disruption of traffic flow continuity. Despite the emergence of intelligent networking technologies such as software-defined networking, network cloudification, and network function virtualization, they still need to improve their performance. Our proposal provides a novel solution to tackle traffic flow continuity by controlling the selected packet header bits (Differentiated Services Code Point (DSCP)) that govern the traffic flow priority. By setting the DSCP bits, we can determine the appropriate p

... Show More
View Publication
Crossref (1)
Scopus Crossref
Publication Date
Thu Aug 15 2019
Journal Name
Arab World English Journal For Translation And Literary Studies
Silence as a Tactic of Communication in Pragmatics, Novel, and Poetry
...Show More Authors

View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Thu May 01 2025
Journal Name
Applied Data Science And Analysis
Strengthening cloud data protection based on a novel cyber security framework
...Show More Authors

Cybersecurity involves protecting computer networks, systems, and data from unauthorized access and disruptions using advanced technologies. The purpose of this research is to establish a novel cyber security framework for strengthening cloud data protection. In this paper, we propose a novel Dung Beetle optimization-redefined Intelligent Random Forest (DB-IRF) for accurate detection of intrusions in a cloud environment. We obtained a dataset that includes cloud system logs and network traffic data, including normal and malicious activities, to train our proposed model. We utilized z-score normalization to pre-process the gathered raw data. Our suggested model enhances classification accuracy by integrating DB optimization with the

... Show More
View Publication Preview PDF
Crossref (3)
Crossref
Publication Date
Wed Jan 24 2018
Journal Name
The Journal Of Physical Chemistry C
Novel Approach for Fabricating Transparent and Conducting SWCNTs/ITO Thin Films for Optoelectronic Applications
...Show More Authors

View Publication
Scopus (35)
Crossref (40)
Scopus Clarivate Crossref
Publication Date
Thu May 05 2022
Journal Name
Al-kindy College Medical Journal
Safety profile of immediate post-partum intrauterine device insertion during caesarean delivery – a clinical trial with three years of follow up: Utility of Immediate Post Placental Insertion of Intrauterine Device During Cesarean Delivery
...Show More Authors

Background: Many countries recommend the use of long-acting reversible contraceptive intrauterine device immediately after cesarean delivery. The cesarean delivery rate in Iraqi public hospitals is 32.2% and may reach 85.8% in private hospitals. Immediate post-partum intrauterine device insertion at cesarean is rarely done in Iraq.

Objectives: To assess the safety and practicality of immediate post-partum intrauterine device insertion during cesarean delivery for family planning and pregnancy spacing in Iraqi women.

Subjects and Methods: A single arm clinical trial included 150 eligible women who attended Al-‎Elwiyah Maternity Teaching Hospital or Al Hayat Rahibat Hospita

... Show More
View Publication Preview PDF
Crossref
Publication Date
Fri Sep 01 2017
Journal Name
Ce/papers
16.15: Experimental evaluation of a novel demountable shear connector for accelerated repair or replacement of precast steel‐concrete composite bridges
...Show More Authors

A novel demountable shear connector for precast steel‐concrete composite bridges is presented. The connector uses high‐strength steel bolts, which are fastened to the top flange of the steel beam with the aid of a special locking nut configuration that prevents slip of bolts within their holes. Moreover, the connector promotes accelerated construction and overcomes typical construction tolerances issues of precast structures. Most importantly, the connector allows bridge disassembly, and therefore, can address different bridge deterioration scenarios with minimum disturbance to traffic flow, i.e. (i) precast deck panels can be rapidly uplifted and replaced; (ii) connectors can be rapidly removed and replaced; and (iii) steel beams can b

... Show More
View Publication
Crossref (2)
Crossref
Publication Date
Wed Jul 01 2026
Journal Name
Journal Of Energy Storage
Novel multi-lobed tube designs for efficient latent thermal energy storage: A comprehensive study of single and dual-tube configurations
...Show More Authors

View Publication
Scopus Crossref
Publication Date
Tue Jul 09 2024
Journal Name
Diagnostics
A Novel Hybrid Machine Learning-Based System Using Deep Learning Techniques and Meta-Heuristic Algorithms for Various Medical Datatypes Classification
...Show More Authors

Medicine is one of the fields where the advancement of computer science is making significant progress. Some diseases require an immediate diagnosis in order to improve patient outcomes. The usage of computers in medicine improves precision and accelerates data processing and diagnosis. In order to categorize biological images, hybrid machine learning, a combination of various deep learning approaches, was utilized, and a meta-heuristic algorithm was provided in this research. In addition, two different medical datasets were introduced, one covering the magnetic resonance imaging (MRI) of brain tumors and the other dealing with chest X-rays (CXRs) of COVID-19. These datasets were introduced to the combination network that contained deep lea

... Show More
View Publication
Scopus (8)
Crossref (10)
Scopus Clarivate Crossref
Publication Date
Mon May 01 2017
Journal Name
Journal Of Nuclear Medicine
Capability of a novel small field of view hybrid gamma camera (HGC) for sentinel lymph node and small organ imaging
...Show More Authors

Objectives: Small field of view gamma detection and imaging technologies for monitoring in vivo tracer uptake are rapidly expanding and being introduced for bed-side imaging and image guided surgical procedures. The Hybrid Gamma Camera (HGC) has been developed to enhance the localization of targeted radiopharmaceuticals during surgical procedures; for example in sentinel lymph node (SLN) biopsies and for bed-side imaging in procedures such as lacrimal drainage imaging and thyroid scanning. In this study, a prototype anthropomorphic head and neck phantom has been designed, constructed, and evaluated using representative modelled medical scenarios to study the capability of the HGC to detect SLNs and image small organs. Methods: An anthropom

... Show More