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Effect of Metformin Treatment on some Blood Biomarkers in Women with Endometriosis.
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 Endometriosis is a common women health disorder that occurs when Endometrial-like tissue grows outside the uterus. This may lead to irregular bleeding , pelvic pain, infertility and other complications.   Metformin,  because of its activity to improve  insulin sensitivity, it is  used for  the treatment of diabetes; it  also  has a modulatory  effect  on  ovarian  steroid  production and has  anti-inflammatory  properties,  all may  suggest  its possible effect in treatment  of endometriosis. This  study  was  planned  to  determine  the  effect  of  metformin  on serum levels  of  interleukin- eight(IL-8),  Tumor  necrosis  factor-alpha (TNF –α)  and estradiol (E2)  production , and  related  symptomatic  changes  that  accompany  with endometriosis  (pelvic  pain,  dysmenorrhea  and  menorrheaga)  after  three months of study. Blood samples were obtained from those taking  metformin and measure the serum levels of (IL-8) , TNF –α and (E2) were measured before and after three months of taking a  metformin .Metformin  therapy  resulted  in  a  significant  reduction  in  the  clinical symptoms  of  endometriosis  (pelvic  pain  and  dysmenorrhea)  and insignificant changes in menorrhagia. Metformin therapy resulted in a  significant  reduction  in the serum levels of  IL-8,  TNF-  α while  insignificant  reduction  in  estradiol  E 2  in  the  study  group after 3 months of treatment .In conclusion the results of this study, demonstrated that metformin may be a well-tolerated  treatment  for  endometriosis  that  relieved  pain  and reduces  menstrual disorders and serum  levels  of  the  inflammatory  markers  (IL-8  and  TNF-α)  are decreased  in study  group treated  with metformin after 3 months due to its   anti-  inflammatory effects.

Keywords: Endometriosis, Metformin, TNF – a ,IL-8, E 2.

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Publication Date
Fri Jun 16 2023
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Autophagy or Apoptosis: Anticancer Molecular Mechanism of Epigallocatechin Gallate with Natural Polyphenol Effect on HepG2 Cells Viability
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Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied.  Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptos

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Publication Date
Mon Jan 11 2021
Journal Name
Engineering, Technology & Applied Science Research
The Effect of Low Velocity Impact Loading on SelfCompacting Concrete Reinforced with Carbon Fiber Reinforced Polymers
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t-Self-Compacting Concrete (SCC) reduces environmental noise and has more workability. This research presents an investigation of the behavior of SCC under mechanical loading (impact loading). Two types of cement have been used to produce SCC mixtures, Ordinary Portland Cement (OPC) and Portland Limestone Cement (PLC), which reduces the emission of carbon dioxide during the manufacturing process. The mixes were reinforced with Carbon Fiber Reinforced Polymer (CFRP) which is usually used to improve the seismic performance of masonry walls, to replace lost steel reinforcements, or to increase column strength and ductility. Workability tests were carried out for fresh SCC. Prepared concrete slabs of 500×500×50mm were tested for lo

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Publication Date
Mon Jun 01 2026
Journal Name
Surra Man Ra'a
The cultural effect on translating titles of an international Awareness Campaigns with reference from English to Arabic
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The study explains how translation participates in shaping the responses of different communities to global awareness campaigns, and the extent to which language and translated terminology from English to Arabic influence the audience’s understanding and interaction with the awareness messages delivered by these campaigns. The research aims to explore the problems in translating these campaign titles, which may lead to vague meaning, as the process is considered a major challenge due to the need to navigate linguistic nuances, cultural differences, and contextual variations. In this study, some awareness phrases were randomly chosen from many types of organizations’ campaigns, like the WHO, UN, mental health, and Empowerment, a

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Publication Date
Mon Sep 30 2024
Journal Name
Journal Of Language Studies
Weeping of Women and Nature in Tess Onwueme’s Then She Said It!
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This study explores the theory of Ecofeminism ,which elucidates how capitalism and patriarchal society treat women and nature. Moreover, it studies the effects of gender categories to show how social norms unfairly control women and the environment. This study explores how Tess Onwueme's Then She Said it dramatizes the combined tyranny of nature and women. It emphasizes the devastation caused by oil firms colluding with local authorities to exploit both. The playwright examines the historical oppression of Delta women and the environmental damage they endure, using dramatic visuals and dialogue to illustrate the harsh realities of pollution and poverty. This study examines the contradiction between the prosperity of oil companies and the po

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Publication Date
Sat Jan 01 2022
Journal Name
Journal Of Pharmaceutical Negative Results
The Level of Nitric Oxide Synthase and Nitric Oxide in Hypertensive Women
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Hypertension is a cardiovascular problem with high rates of epidemiology and risks of morbidity and mortality in the global area. Nitric oxide (NO) is one of the reactive oxygen species (ROS) that produced from L-arginine by nitric oxide synthase (NOS) enzyme. NO involves in various vital processes in human health, one of which is the modulation of vasoconstriction and relaxation of the vascular system. We have aimed to investigate the link between NO and NOS with hypertension in women. The relationship between NO and NOS, as well as the usefulness of them as indicators of hypertension risks were subjects of study in this article. The results have revealed that hypertensive women had significant (P<0.05) lower levels of NO (15.07±3.41 IU/m

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Publication Date
Tue Sep 15 2020
Journal Name
Al-academy
The Image of Women in Arab Media Advertisements: معجب بن عثمان الزهراني
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Advertisements containing images of women represent one of the most controversial topics of the advertising industry and has an impact on people and trends. This study aims to determine the typical mental image of women purveyed through visual advertising in the Arab media. It also aims to find out whether these advertisements portray women positively or negatively, in addition to investigating the reasons for the recent negative portrayal of women in commercials. The study adopted a descriptive-analytical approach to achieve these objectives. The results indicate that advertising designs that carry images of women displayed in the Arab media create strong mental images. Repetition reinforces these images, and they emphasize the concept

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Publication Date
Mon Dec 30 2019
Journal Name
College Of Islamic Sciences
Extremism in religion Causes, effects and treatment
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Praise be to God, Lord of the worlds, and prayers and peace be upon His messenger, the mercy of the worlds.
As for after ....
It is clear from the legal texts in the Noble Qur’an and the Sunnah of the Prophet, that Islam is a method that interferes in everything in beliefs, worship, behavior and transactions, and it forbids excess and extremism and mistrust of people and looking at them through a black lens, self-conceit and contempt of others.
In our research, we will try, God willing, to study the phenomenon of religious extremism with its comprehensive dimensions, the position of Islam on it through the verses and hadiths discussed by it, and the diagnosis of the reasons for its emergence and emergence, because if we learn

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Publication Date
Fri Feb 08 2019
Journal Name
Journal Of The College Of Education For Women
Dialectical perspective and treatment in poetry of Khalil Hawi
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Were not experience Khalil Hawi capillary module as presented or routine in the format
of the implications , but was saturated transitions quality that targeted built by visionary and
mechanisms expressive , Valgosaidp when the container is a clash between two worlds world
Nahdi to promote world on the ashes , and often strained poet himself to achieve an approach
between worlds , and in the midst of those caesarean section exhausted poet in touch his tools
and visions , and this is why the poetry Hawi toward westernization expressive as a result of
the conflict concepts chronic , be sure to researcher not engaged in the overall qualitative
changes in the structure and content, but the goal Acetknah level that qualit

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Publication Date
Thu Apr 21 2016
Journal Name
Iraqi Dental Journal
Amoxicillin vs Levofloxacin in Treatment of Chronic Periodontitis: Review
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Publication Date
Fri Dec 01 2017
Journal Name
The Iraqi Postgraduate Medical Journal
Extensive Versus Traditional Phototherapy in Treatment of Neonatal Jaundice
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