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bijps-1917
Evaluation of Antileishmanial Activity of Osteospermum ecklonis Extract of Aerial Parts against Leishmania donovani: in vitro(Conference Paper) #
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Abstract

 

Lack of safe available non-resistant treatment for visceral leishmaniasis (Kala-azar) keeps limiting the complete cure of this disease ,drugs that have  toxic side effects or lack of effectiveness  have led to disease relapse ,all these factors have lightened  the way to the search for imperative drugs from natural resources that have been shown to have antileishmanial activity through literature survey

. In the present study, the comparative in vitro anti-leishmania activity of various fractions of Osteospermum ecklonis aerial parts fractions have been evaluated. Extracts were prepared through maceration and Soxhlet apparatus using 85% methanol and fractionation was done by separating the active constituents according to the differences in their polarities using petroleum ether and n-butanol respectively. The resultant fractions( petroleum ether as well as n-butanol fractions )were chosen for effective inhibition of Leishmania donovani, The results prove with no doubt that the petroleum ether fraction of the maceration aerial parts in a concentration of 2.5 mg/ml had better antileishmanial activity than other concentrations of tested samples and the result coincided with the anti-leishmaniasis activity of official treatment (pentostam®) ,This finding  can be attributed to the terpene nature of the materials used to be existed in such fraction. This observation have paved the road to step in for extended studies in relation to the conventional herbal medicines for better and safe alternatives to available synthetic chemical drugs.

 

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Publication Date
Fri Dec 20 2019
Journal Name
College Of Islamic Sciences
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Tue Jun 15 2021
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The authority of identification and alienation of existence in the theater of the oppressed: عبلة عباس خضير التميمي
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Sat Mar 26 2022
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The role of the marketing intelligence system in the quality of the insurance service : Applied research in the National Insurance Company
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Publication Date
Sat Sep 15 2018
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Estimation of the Risk of Water Erosion in Jawarta District in Sulaymaniyah Governorate Using the Global Equation for Soil Loss (USLE)
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Publication Date
Tue May 12 2026
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The role of leadership skills in organizational trust Analytical research center in the Ministry of Higher Education and Scientific Research, Iraq
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Sun Sep 01 2019
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The effect of accounting disclosure in the efficient performance of the tax authority: Applied research in the General Commission for Taxes
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Crossref
Publication Date
Fri Dec 01 2017
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The Role of Media in Developing the Tax Awareness of the Iraqi Citizen: Applied Study in the General Commission for Taxes
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Wed Apr 01 2026
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