The 3-aminoacetophenone and 4-aminoantipyrine were used as precursors to prepare new six ligands. The three new ligands (L1,L2 and L3) were synthesis by reacting one mole of 3-aminoacetophenone with one mole of (Acetyl chloride), (benzoyl chloride), (4-methoxybenzoyl chloride) and ammonium thiocyanat in acetone as a solvent, they are:- L1 (AAA) =[N-(3-acetylphenylcarbamothioyl)acetamide] L2 (BAA) =[N-(3-acetylphenylcarbamothioyl)benzamide] L3 (MAA) =[N-(3-acetylphenylcarbamothioyl)-4-methoxy benzamide] Also three new derivatives of 4-aminoantipyrine were synthesis by reacting one mole of 4-aminoantipyrine with one mole of (Acetyl chloride), (benzoyl chloride), (4-methoxybenzoyl chloride) and ammonium thiocyanat in acetone as solvent and the ligands are given: L4 (AAD) =[N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylcarbamothioyl)acetamide] L5 (BAD) =[N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylcarbamothioyl)benzamide] L6 (MAD) =[N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylcarbamothioyl)-4-methoxybenzamide] These ligands were identified by FT-IR ,1H,13C-NMR,elemental analysis(C.H.N.S), electronic spectra, the molecular formula of there were concluded:- L1 (AAA) = C11H12O2N2S L2 (BAA) = C16H14O2N2S L3 (MAA) = C17H16O3N2S L4 (AAD) = C14H16N4O2S L5 (BAD) = C19H18O2N4S L6 (MAD) = C20H20O3N4S The ligands were reacted with some metal ions (M+2 =VO, Mn, Co, Ni, Cu, Zn, Cd , Hg and Pd), to give complexes with molecular formulas:- [M(AAA)2(H2O)2]Cl2 , [M(BAA)2(H2O)2]Cl2 , [M(MAA)2(H2O)2]Cl2, [M(AAD)2(H2O)2]Cl2 , [M(BAD)2(H2O)2]Cl2, [M(MAD)2(H2O)2]Cl2 Where (M+2 = Mn, Co, Ni, Cu, Zn, Cd , Hg and Pd) [VO(AAA)2]SO4 , [VO(BAA)2]SO4 , [VO(MAA)2]SO4, [VO(AAD)2]SO4 , [VO(BAD)2]SO4, [VO(MAD)2]SO4 The complexes were characterized by solubility, melting point and decomposition, FT-IR, electronic spectra, molar conductivity, magnetic susceptibility measurements, element microanalysis for some complexes and flame atomic absorption. From above results, one can conclude that complexes of (M+2 = Mn, Co, Ni, Cu, Zn, Cd, Hg and Pd) have an octahedral geometry while the square pyramid for complexes for(VO+2) The biological effects of ligands and some of their complexes have been investigated on two types of bacteria species Staphylococcus aureu a gram positive and Escherichia coli a gram negative In agricultural agar medium, the results exhibited all the compounds (expect Ni2+ with L1)have varsity anti bacterial activities
RKASFH Ghanim, Ibn Al -Haitham Journal for pure and applied science, 2017
In search of novel antibacterial agent, a series of new isatin derivatives (3a-d) have been synthesized by condensation isatin (2,3-indolinendione) with piperidine (hexahydropyridine), hydrazine hydrate and Boc-amino acids respectively. Compounds synthesized have been characterized by IR spectroscopy and elemental analysis. In addition, the in vitro antibacterial properties have been tested against E. coli, P. aeruginosa, and Bacillus cereus, S. aureus by employing the well diffusion technique. A majority of the synthesized compounds were showing good antibacterial activity and from comparisons of the compounds, compound 3d has been determined to be the most active compound.
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Preparation and Identification of some new Pyrazolopyrin derivatives and their Polymerizations study
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The present work involved synthesis of several new N-Sulfamethoxazol derivatives imide on Polymeric chain by two steps. The first stip involved preparation of N- (sub.orunsub benzoyl and sub unsub acetyl) amidyl sub sulfamethoxazole (1-5) by condensation of sulfamethoxazole drug with many substituted acid chloride, then the second step include, preparation new five N-(acrly-N–sub or unsub benzoyl) imidyl substituted sulfamethoxazol(6-10) by reaction of poly acryloyl chloride with the prepared compound (1-5) in first stepin asuitable solvent in the presenceamount triethylamine (Et3N) with heating. The structure confirmations of all polymers wereconfirmed using FT-IR,1H-NMR,13C-NMR and UV spectroscopy. Other physical properties including so
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New biscarboxylato zwitterionic ligands, namely bis(N-carboxylatoethyl)-4,4 -dipyridinum) L1 and bis(Ncarboxylatopropyl)-)-4,4 -dipyridinum) L2, were synthesized from the reaction of 4,4 -dipyridine with 3-bromopropanoic acid and 4-bromobutanoic acid, respectively. The reaction of these ligands and the azido coligand with some metal ions resulted in the formation of polymeric complexes of general formulae [Cr2(Ln)(N3)4]Cl2·H2O and [M2(Ln)(N3)4] xH2O, where (M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II); n = 1, 2; x = 1, 1, 1, 1, 0, 1, and 1, respectively.) The oxygens of the carboxylato group are coordinated to the metal ion in a bidentate fashion. The mode of bonding and overall geometry of the complexes were determin
... Show MoreAromaticity, antiaromaticity and chemical bonding in the ground (S0), first singlet excited (S1) and lowest triplet (T1) electronic states of disulfur dinitride, S2N2, were investigated by analysing the isotropic magnetic shielding, σiso(r), in the space surrounding the molecule for each electronic state. The σiso(r) values were calculated by state-optimized CASSCF/cc-pVTZ wave functions with 22 electrons in 16 orbitals constructed from gauge-including atomic orbitals (GIAOs). The S1 and T1 electronic states were confirmed as 11Au and 13B3u, respectively, through linear response CC3/aug-cc-pVTZ calculations of the vertical excitation energies for eight singlet (S1–S8) and eight triplet (T1–T8) electronic states. The aromaticities of S
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