Preferred Language
Articles
/
_uZ2k5wBmraWrQ4dpUsr
Solubility and Dissolution Rate Enhancement of Bilastine by Solid Dispersion Technique
...Show More Authors

Bilastine (BLS) is non-sedating new-brand H1 antihistamine that has selective peripheral effects, the drug has a problem of an insufficient aqueous solubility and accordingly low dissolution rate, and low bioavailability. Solid dispersion (SD) is one of the most effective techniques for improving the solubility and the dissolution rate of poorly soluble drugs by the dispersion of drug within an inert hydrophilic carrier.   The aim of this study is to increase the solubility and dissolution rate of the BLS using SD technique. Twenty-nine BLS SD formulas were prepared using different carrier polymers include Pluronic 407 (Poloxamer407), Poloxamer188, Urea, Polyethylene glycol 6000 (PEG6000) and Polyvinylpyrrolidone (PVP K30) and employing two different preparation methods (solvent evaporation and kneading method) at different drug: polymer ratios (1:1 ,1:3,1:5,1:10,1:15). The prepared SD formulas were evaluated for their percent yield, drug content, aqueous solubility, dissolution rate, PXRD, and FTIR. The SD technique successfully improved the solubility and dissolution rate of BLS. The improvement was largely dependent on the polymer type and drug: polymer ratio. The solubility improvement using different polymers was in the following order: PVP K30> PLX188> PEG6000> Urea> PLX407. The solid dispersion formula that showed the best outcomes in terms of dissolution improvement was prepared using the solvent evaporation technique employing PVP K30 at ratio of drug: polymer of 1:15. The optimized formula showed 10.2 folds increment in the solubility compared to pure BLS. It can be concluded that the SD technique can successfully improve the solubility and dissolution rate by solvent evaporation method with careful selection of the carrier polymer and drug: polymer ratio.

Scopus Crossref
View Publication
Publication Date
Fri Mar 14 2003
Journal Name
Journal Of Engineering
Slope Stability of Embankments by the Finite Element Method
...Show More Authors

Publication Date
Sun Mar 01 2009
Journal Name
Baghdad Science Journal
Corrosion inhibition of Zinc by Imidazol in Acidic Media
...Show More Authors

The inhibitive effect of imidazol on the dissolution of Zn in (1M) HCl has been studied. The inhibion effect of imidazol ,protection efficiency and the corrosion rate of Zn in (1M) HCl were investigated at various concentrations (1x 10-3 – 5x10-3) M and tempearture range (285-328) K. The corrosion inhibitive of Zn by imidazol was studied using weight loss measurement and analytical titration of the amounts of dissolved zinc in acidic solution in presence and absent of imidazol. It was observed that imidazol led to protection efficiency reached to (88.93)% when (10)mM imidazol concentration was used. A linear relationship came true between (C/?) and (C); where (?) is the coverage of Zn surface by imidazol which could be obtained from

... Show More
View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Sat Jun 01 2019
Journal Name
Iop Conference Series: Materials Science And Engineering
Characterizations of Fe/Mn binary oxide by nitrogen adsorption
...Show More Authors

View Publication Preview PDF
Scopus (3)
Crossref (3)
Scopus Crossref
Publication Date
Tue Dec 30 2008
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
Separation of Hexane-Benzene Mixtures by Emulsion Liquid Membrane.
...Show More Authors

The effect of operating parameters on the batch scale separation of hydrocarbon mixture (benzene and hexane) using
emulsion liquid membrane technique is reported. Sparkleen detergent was used as surfactant and heavy mineral oil as
solvent to receive the permeates.
From the experimental results, the parameters that influenced the permeation are, composition of feed, contact time
with solvent, ratio of volume of solvent to volume of hydrocarbon feed, ratio of volume of surfactant solution to volume
of hydrocarbon feed, surfactant concentration, mixing intensity and glycerol as polar additive in the surfactant solution
to eliminate drop breakup.
The best conditions for the separation in this study were found to be: comp

... Show More
View Publication Preview PDF
Publication Date
Sat Aug 31 2019
Journal Name
Iraqi Journal Of Physics
Spectroscopic Diagnostic of Cadmium Sulfide Plasma Produced By LIBS
...Show More Authors

Abstract

       The current study was carried out to reveal the plasma parameters such as ,the electron temperature ( ), electron density (ne) , plasma frequency (fp), Debye length ( ) , Debye number (   for  CdS to employ the LIBS for the purpose of analyzing and determining spectral emission lines using . The results of electron temperature for CdS range (0.746-0.856) eV , the electron density(3.909-4.691)×1018 cm-3. Finally ,we discuss plasma parameters of CdS  through  nano second  laser generated plasma .

View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Fri Jan 01 2021
Journal Name
Materials Today: Proceedings
Pyrolysis of scrap tire by utilizing zeolite as catalyst
...Show More Authors

View Publication
Scopus (11)
Crossref (4)
Scopus Clarivate Crossref
Publication Date
Mon Feb 01 2021
Journal Name
Iop Conference Series: Materials Science And Engineering
Separation of oil/water emulsions by microbubble air flotation
...Show More Authors
Abstract<p>Oil/water emulsions are one of the major threats to environment nowadays, occurs at many stages in the production and treatment of crude oil. The oil recovery process adopted will depend on how the oil is present in the water stream. Oil can be found as free oil, as an unstable oil/water emulsion and also as a highly stable oil/water emulsion. The current study was dedicated to the application of microbubble air flotation process for the removal of such oily emulsions for its characters of cost-effective, simple structure, high efficiency and no secondary pollution. The influence of several key parameters on the process removal efficiency was examined, namely, initial oil concentration, pH value of t</p> ... Show More
View Publication
Crossref (21)
Crossref
Publication Date
Sat Mar 30 2002
Journal Name
Iraqi Journal Of Chemical And Petroleum Engineering
D-Sorbitol Production by Catalytic Hydrogenation of D-Glucose
...Show More Authors

View Publication Preview PDF
Publication Date
Sun Jun 01 2014
Journal Name
Soils And Foundations
Studying collapse potential of gypseous soil treated by grouting
...Show More Authors

View Publication
Crossref (51)
Crossref
Publication Date
Fri Feb 17 2012
Journal Name
Smart Materials And Structures
Frequency tuning of piezoelectric energy harvesters by magnetic force
...Show More Authors

View Publication
Scopus (114)
Crossref (105)
Scopus Clarivate Crossref