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Association of IL-37 Levels with Liver Function Enzymes in a Sample of Iraqi HBV-Infected Patients
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Background: Despite extensive efforts towards its elimination, Hepatitis B virus (HBV) continues to be a major concern, posing risk of liver cirrhosis and hepatocellular carcinoma (HCC) in those infected. Therefore, there is a need for reliable biomarkers to accurately assess the infection. While liver enzymes remain the standard diagnostic tools, the anti-inflammatory and anti-tumor interleukin-37 (IL-37) has emerged as a potential biomarker. Aims: To assess the relationship between serum IL-37 and liver enzymes in HBV patients. Methods: Liver enzymes were measured by Fujifilm’s dry chemistry system (Fuji Dri-Chem), whereas Enzyme-Linked Immunosorbent Assay (ELISA) was utilized for determination of IL-37 levels. A total of 100 patients (37 females, 63 males; mean age: 42 years) from the Medical City in Baghdad, along with 50 age/sex-matched controls (23 females, 27 males; mean age: 38 years) were enrolled in this study. Results: The study has demonstrated highly significant variation in TSB, GOT, and ALP (P<0.01) between patients and controls. Additionally, Sex-based differences in TSB and GOT also showed a significant variation (P<0.01), and the diagnostic value was confirmed by receiver operating characteristic (ROC) curve analysis. Furthermore, a high significant divergence in IL-37 levels was observed between patients and controls [P<0.01, IQR: 32.4 vs. 61.4 Picogram/Milliliter (pg/mL), respectively], with ROC analysis supporting its clinical relevance (P<0.01). Also, significant variation was noted in levels of IL-37 in correlation with HBV serological markers, particularly in patients with negative HBsAg and anti-HBcAb (119.8 vs 63.16 pg/mL, respectively). Conclusions: IL-37, in combination with liver enzymes, may serve as a valuable biomarker panel for monitoring HBV infection.

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Publication Date
Sun Jun 01 2014
Journal Name
Journal Of Natural Science Research
Sialic Acid Is A Novel Biochemical Marker In Sera Of Iraqi Endometriotic Patients
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ABSTRACT : Alzheimer’s disease (AD) is one of the most common inflammatory neurodegenerative diseases linked with dementia, it is characterized by the deposition of amyloid beta-peptide (Ab) in the brain. The present study aims to innovate a biochemical relationship between AD and interleukin 38 (IL-38) as an anti-inflammatory cytokine, expose novel mechanisms and concepts regarding other biochemical parameters studied previously or recently in AD patients and also examine the biochemical action of memantine (10 mg daily) on AD patients. Sixty (60) diagnosed AD patients participated in the present study and classified into four (4) groups: G3 were composed of (15) newly diagnosed males (52-78) years / without treatment, G4 composed of (15

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Publication Date
Thu Mar 07 2024
Journal Name
Problems Of Endocrinology
KI-67 as a predictive indicator of papillary thyroid cancer in Iraqi patients
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BACKGROUND. KI-67 (MKI-67 in humans) is a protein able to bind to DNA which contributes to cell growth and cell proliferation. KI-67 is currently considered as a biomarker that is widely utilized as prognostic indicator for evaluating cell proliferation, diagnosing diseases, and conducting research. Several different kinds of cancer have high Ki-67 expression, which simplifying the choice of treatment for individuals with various cancer types.AIM. The objective was to evaluate the expression of KI67 in patients suffering papillary thyroid cancer (PTC) also the association between patients age and gender and KI67 expression.MATERIALS AND METHODS. To undertake an in-

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Publication Date
Thu Jan 23 2020
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
EFFECT OF DECISION OF INCREASING THE MINIMUM LIMIT OF THE CAPITAL IN THE IRAQI PRIVATE BANKING ACTIVITY: APPLIED STUDY IN A SAMPLE OF PRIVATE IRAQI BANKS
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This research aims to show the sight at the importance of the private banking sector in Iraq and its role in financing of the investment projects , of the ability of Central Bank's decision to increase the minimum limit of capital for private banks to provide support to the economic activity and the development in Iraq. In addition to illustrate the importance of the capital increase, with a, and taking into notice the most important determinants that can stand in front of these banks in the beginning of the decision implementation, which in turn can lead to the most important proceedings that can contribute in the support of banks to implementation the decision.  Also, the research has highlighted the most important ways through wh

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Publication Date
Sun Sep 01 2024
Journal Name
The Scientific World Journal
Serum Level Alteration of IL‐6, IL‐1<i>β</i>, and IFN‐<i>γ</i> in Groups of Healthy Adults with Oxidative DNA Damage in Najaf Governorate
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Background. Najaf governorate was recorded as one of the most polluted Iraqi governorates with increased cancer, autoimmune, and abortion cases. Study Groups. A total of 88 adult volunteers from three test groups were divided based on their inhabitance in different geographical regions in Najaf governorate. Group 1 (G1; n, 29) inhabitants of Al‐Ansar, Al‐Abbaseyeh, and Al‐Manathera districts, Group 2 (G2; n, 27) inhabitants of 22 different scattered districts of the governorate, Group 3 (G3; n, 32) inhabitants of Kufa city and center districts in the old Najaf city. According to previous author

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Publication Date
Wed Jan 20 2021
Journal Name
Journal Of Applied Sciences And Nanotechnology
Correlation of MicroRNAs-122a Gene Expression with Diabetic for Iraqi Patients
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This study was carried out to describe the gene expression of the micro RNA 122a gene with the development of diabetes in Iraq. The difference in gene expression between patients and healthy controls was properly considered. In this study, blood was isolated from 121 individuals divided into two groups as follows: 80 samples of diabetic patients and 41 samples from a healthy control. miRNA was isolated and transformed into cDNA, and the expression of mi122a was measured by qRT-PCR. The researchers looked at the relationship between age and gender and the occurrence of diabetes, as well as how they compared to controls. When comparing the mean gene expression level (Ct) of patient groups to the corresponding Ct means in the control group, th

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Publication Date
Sun Apr 01 2007
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Isolation of some microorganisms from Iraqi patients with chronic maxillary sinusitis.
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Publication Date
Wed Apr 01 2026
Journal Name
Israa University Journal For Applied Science
The histopathological changes in the liver of infant mice with Cronobacter sakazakii
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Background and Aim: The present study aimed to investigate the pathogenic ability of Cronobacter sakazakii in neonatal mice through the evaluation of its effect on liver tissue and the associated histopathological changes . Methods: Isolates of C. sakazakii were obtained from the Microbiology and Molecular Laboratory, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, and were confirmed by 16S rRNA sequencing from samples of infant formula, spinal fluid, and blood. Forty-five neonatal mice aged between 10 and 16 days were obtained from the Iraqi Center for Cancer and Medical Genetics. The animals were divided into three experimental groups, the first group as a control and given only distilled water, the

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Publication Date
Sat Dec 24 2022
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Occurrence of Quinolone-Resistance Genes in Ciprofloxacin-Resistant Salmonella Enterica Serotype Typhi Isolated form Blood Sample of Patients with Typhoid Fever
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Salmonella is approved as a common foodborne pathogen, causing major health problems throughout the world particularly in low‐ and middle‐income countries. Low-level fluoroquinolone resistance is conferred by both chromosomal and plasmid-encoded resistance, this research was carried out look into the occurrence rate of qnrA,qnrB and qnrS genes  in  Salmonella enterica serotype Typhi Cipr  ofloxacin-resistant insulate from blood samples of patients with typhoid fever. Fifteen Salmonella enterica serotype Typhi isolated previously from patients with typhoid fever were included in this study. All bacterial isolates were confirmed to have ciprofloxacin

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Publication Date
Thu Jun 30 2011
Journal Name
Al-kindy College Medical Journal
Serum Lipoprotein (A) in Patients with Fibromyalgia Syndrome
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Background: Fibromyalgia syndrome (FMS) is the
most common rheumatic cause of diffuse pain and
multiple regional musculoskeletal pain and disability.
Objective: is to assess the contribution of serum
lipoprotein (A) in the pathogenesis of FMS patients.
Methods: One hundred twenty two FMS patients
were compared with 60 healthy control individuals
who were age and sex matched. All FMS features and
criteria are applied for patients and controls; patients
with secondary FMS were excluded. Serum
Lipoprotein (A): [Lp(A)], body mass index (BMI), &
s.lipid profile were determined for both groups.
Results: There was a statistical significant difference
between patients &controls in serum lipoprotein

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Publication Date
Thu Jan 01 2026
Journal Name
International Journal Of Dentistry
Association of Salivary HIF‐1α Level With Epithelial and Mesenchymal Markers in Smokers and Nonsmokers With Periodontitis: A Case‐Control Study
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Objectives

This case–control study aimed to investigate the relationship between the hypoxia‐related biomarker hypoxia‐inducible factor‐1α (HIF‐1α) and the epithelial‐mesenchymal transition (EMT)–associated markers E‐cadherin (E‐CAD) and N‐cadherin (N‐CAD) in saliva among smokers and nonsmokers with and without periodontitis and to assess their association with clinical periodontal parameters.

Methods

A case–control study was conducted, including 88 participants equally a

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