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XuaJOp0BmraWrQ4doVQC
Synergistic Antibacterial and Anticancer Effects of a Biohybrid Composed of Zinc Oxide Nanoparticles and <i>Streptococcus Salivarius</i> Bacteriocin
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ABSTRACT<p> Antimicrobial therapies are desperately needed since the threat posed by multidrug‐resistant (MDR) bacteria only grows. Bacteriocins produced by <italic>Streptococcus salivarius</italic> possess promising antibacterial properties, yet their practical application is hindered by low production yield and limited stability. Here, we report the green synthesis of a novel biohybrid by conjugating purified <italic>S. salivarius</italic> bacteriocins with zinc oxide nanoparticles (ZnONPs), aiming to enhance bacteriocin stability and antimicrobial efficacy. The successful creation of well‐dispersed nanohybrids was validated by thorough characterization using x‐ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM), exhibiting predominantly cubic and spherical morphologies with sizes ranging from 8 to 68 nm. The ZnONPs–bacteriocin nanohybrids demonstrated pronounced antibacterial activity against both Gram‐positive and Gram‐negative MDR pathogens, as evidenced by significant inhibition zones, and low values for the minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC). In vitro cytotoxicity, assays revealed a dose‐dependent reduction in the viability of both cancerous (A375) and normal (HdFn) cell lines. The nanohybrid displayed greater cytotoxicity toward A375 cells (IC <sub>50</sub> = 121.7 µg/mL) than HdFn cells (IC <sub>50</sub> = 161.6 µg/mL), indicating a degree of selectivity. Collectively, our results demonstrate that green‐synthesized ZnONPs–bacteriocin biohybrids are eco‐friendly and exhibit potent, broad‐spectrum antimicrobial and selective cytotoxic activities, suggesting their significant potential for biomedical applications targeting resistant bacterial infections and malignant cells. </p>
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Publication Date
Thu Jun 10 2021
Journal Name
Neuroquantology
Atmospheric Emissions Effects and Mechanism
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Humanity's relationship with the environment is a delicate balance. Since the industrial revolution, the world's population has grown at an exponential rate, and this has a major environmental effect. Deforestation, pollution, and global climate change are just a few of the negative consequences of population and technological growth. Particulates, Sulphur dioxide (SO2), and nitrogen oxides (NOx) are the primary pollutants that harm our health. These contaminants may be directly emitted into the atmosphere (primary pollutants) or formed in the atmosphere from primary pollutants reacting (secondary pollutants. Tropospheric ozone is created When water reacts with volatile organic compounds (VOC) and nitrogen oxides (NOx) in the presen

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Publication Date
Sat Jul 01 2017
Journal Name
Al–bahith Al–a'alami
A Dubbed Turkish Drama and their Effects of the Behavior of Algerian Women: A Survey Study of a Sample of Women – The City of Mesila is a Model
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The study aims to identify the effects of dubbed Turkish drama on the public through the application of a sample of the views of women. The study also attempts to monitor the causes and motives due to the act of observation and to identify the various effects of this act. In order to achieve these goals, the researcher relies on the descriptive approach in addition to the questionnaire and interviews to collect data. It ends with a number of results such as: The study aims to identify the effects of dubbed Turkish drama on the public through the application of a sample of the views of women. The study also attempts to monitor the causes and motives due to the act of observation and to identify the various effects of this act. In ord

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Publication Date
Sun Dec 01 2019
Journal Name
Plant And Archeaf
EFFECT OF SPRAYING IRON AND ZINC CONCENTRATIONS IN GRAIN AND LEAF CONTENT FOR TWO VARIETIES OF WHEAT CROP
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EFFECT OF SPRAYING IRON AND ZINC CONCENTRATIONS IN GRAIN AND LEAF CONTENT FOR TWO VARIETIES OF WHEAT CROP

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Publication Date
Sun Mar 13 2011
Journal Name
Baghdad Science Journal
Impact of Rhizobial strains Mixture, Phosphorus and Zinc Applications in Nodulation and Yield of Bean(Phaseolus vulgaris L.)
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Pot experiment was carried out at the College of Agriculture – Baghdad University during autumn season, 2007. Thirteen treatments were formulated to evaluate the effectiveness of four applications of Phosphorus (0, 60, 60×2 and 120 Kg P. h-1) and three applications of Zinc (0, 25×2 mg Zn. L-1 and 50 mg Zn. Kg soil-1) along with inoculating seeds of bean with strains mixture 889 and 1865 and non-inoculated treatment, on nodulation, yield and protein content in seeds (N%). The results showed that inoculated plants exceeded on non-inoculated one in all the studied characteristics. While, P and Zn, applications at the rate of 60×2 kg/ha and 25×2 mg/L respectively, significantly, increased, nodulation, yield, protein content in se

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Publication Date
Thu Jun 08 2023
Journal Name
Egyptian Journal Of Chemistry
Ring Opining polymerization of caprolactone And Antibacterial activity by Mixed Ligand of Metal(II) and (III)
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Reaction of L1 [((E)-N1-(nitrobenzylidene)benzene-1,2-diamine] and L2( m-aminophenol), and one equivalent of di- or tri-valent metals(Cr(ӀӀӀ), Mn(ӀӀ), Fe(ӀӀӀ), Co(ӀӀ), Ni(ӀӀ), Cu(ӀӀ) and Zn(ӀӀ) afforded the complexes [M(L1)(L2)2]Cl, M=Cr(ӀӀӀ) and Fe(ӀӀӀ) and the complexes [M(L1)(L2)2] M= Mn(ӀӀ), Co(ӀӀ), Ni(ӀӀ), Cu(ӀӀ) and Zn(ӀӀ). The structure of the Schiff base ligand and their complexes are characterized by (C:H:N), FT.IR, UV.Vis, 1HNMR, 13CNMR and mass spectral. The presence of metal in the complexes are characterized by flame atomic absorption. The spectral data of the complexes have revealed the octahedral geometry. The (L1), (L2) and mixed ligand metal complexes were screened for their ability as cataly

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Publication Date
Fri Dec 01 2023
Journal Name
Food Bioscience
Green synthesis of silver nanomaterials and evaluation of their antibacterial and antioxidant effectiveness in chicken meat
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Publication Date
Sun Feb 01 2026
Journal Name
Journal Of The Iranian Chemical Society
Synthesis, spectroscopic characterization, thermodynamic studies, and anticancer, antioxidant evaluation of metal ion complexes derived from azo dye
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Synthesis of new Fe+3, Co+2, Cu+2, Ru+3, and Rh+3 complexes of azo ligand; [5-((2-(3 H-1 indol-3-yl) ethyl) diazenyl) quinolin-8-ol], of 1:2 (M: L) and characterized through various techniques. The complexes exhibited octahedral geometries. Thermogravimetric (TGA and DSC) analysis is utilized to study the thermal properties of various compounds and reveal the presence of coordinated water molecules in the complexes. The multi-stage thermal decomposition mechanisms, where the thermal breakdown is ended by the formation of metal oxide as the final stable residue. The antioxidant activity of the ligand and its metal complexes was evaluated using the DPPH free radical scavenging assay and Gallic acid as a standard substance. Among the tested co

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Publication Date
Tue Jan 01 2019
Journal Name
Malaysian Journal Of Biochemistry & Molecular Biology
Evaluation influence of extract of Terfezia claveryi desert truffle, pezizaceae, against Streptococcus pneumoniae, in vivo
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Publication Date
Wed Dec 01 2021
Journal Name
International Journal Of Agricultural And Statistical Sciences
Antibacterial activity of thuja orientalis and green tea in pseudomonas areogenosa infection
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Seven isolates were identified as Pseduomonas aeruginosa from clinical samples. Antibiotic sensitivity test were done to determine their sensitivity to number of antibiotics, the results illustrated all that isolates were resistant to most used antibiotics. The ability of Pseduomonas isolates to produce haemolysin, protease and pyocyanin were detected in this study, all isolates had the ability to produce pyocyanin pigment, hemolysis and protease. The antimicrobial activity of the ethanolic extracts of Thuja orientalis and green tea against P.aeruginosa were investigated. The results showed that both these plant extracts have inhibitory effect against Pseduomonas isolates and it was shown that ethanolic extract of green tea was more efficie

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Publication Date
Sun Sep 30 2018
Journal Name
Bioscience Research
Phytochemical, antibacterial and antioxidant activities of Capparis spinosa L. Cultivated in Iraq
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The Capparis spinosa L. is a species has a great interest in the field of traditional medicine for its pharmacological properties with many bioactive compounds. Our study is aiming at the recovery of this species through a phytochemical analysis and an evaluation of antibacterial and antioxidant activities of leaves of Capparis spinosa L. collected from natural habitats within the region of Al-Jadriya, Baghdad, Iraq. Phytochemical investigation demonstrated the presence of flavonoids, phenols, alkaloids, tannins, and glycosides in the methanolic extract of leaves. The quantitative analysis of total phenolic contents is being performed by Folin-Ciocalteau method and expressed in terms of gallic acid equivalents. C. spinosa exhibited progress

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