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Association of paraoxonase-1 108 C >T gene polymorphism with polycystic ovarian syndrome
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Polycystic ovarian syndrome (PCOS) is increasingly recognized as a significant health concern among women of reproductive age, exerting its influence on the reproductive system and overall female physiology. Paraoxonase-1 (PON1) gene polymorphism, -108 C >T in the promoter region, have been identified as factors that influence both the stability of the enzyme and its active site. This, in turn, contributes to increase oxidative stress, a recognized risk factor associated with PCOS. This study aimed to investigate the connection between paraoxonase-1-108 C >T gen polymorphisms with PCOS in Iraqi women in a case-control study included 40 women with PCOS and 40 women with normal cycles and no symptoms of hyperandrogenism, and no history of PCOS. Whole blood was used to extract the DNA, and using specified sets of primers, the gene fragments corresponding to the -108 C >T were amplified using a conventional polymerase reaction (PCR). Direct sequencing was used to carry out the genotyping and the results showed that the age, body mass index (BMI), and comorbidities of the two groups were similar. The prevalence of homozygous genotype (TT) of the -108 C >T was greater in PCOS women (27.5%) compared to healthy women (10%), with a significant difference (OR= 5.04, 95%CI=1.11-22.97, p=0.037). The prevalence of the mutant allele (T) was found to be greater in women with PCOS (56.25% versus 141.25%) compared to healthy women. This difference was nearly statistically significant (OR=1.85, 95%CI= 0.98–3.43, p= 0.059). These results confirmed the significance of -108 C >T as a risk factor for PCOS in Iraqi women.

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Publication Date
Sat Oct 19 2024
Journal Name
Baghdad Science Journal
The Impact of VDR-FokI Polymorphism in Iraqi Patients with Prostate Cancer and Prostate Benign Hyperplasia.
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استخدم تعدد الطرز الوراثية لمورث مستقبل  فيتامين د عند الموقع FokI لتقييم تاثيرتعدد الطرزالرواثية  على مستويات فيتامين د وهرمون الذكورة وهرمون الحليب في امصال مرضى سرطان البروستات وتضخم البروستات الحميد مقارنة بالأفراد الأصحاء.  تم تضخيم موقع الحصر FOKI لمورث مستقبل فيتامين د باستخدام تقنية TaqMan RT-PCR وجد أن الطراز الوراثيTT   له تأثير حماية من الاصابة  بسرطان البروستات وتضخم البروستات الحميد بنسبة 70% و50 % عل

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Publication Date
Wed Jan 01 2020
Journal Name
Medico-legal Update
Evaluating the concentration of cotinine, lead and cadmium in newborns with respsiratory distress syndrome
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Background Respiratory distress syndrome is one of the most common problems of newborns. Respiratory distress syndrome occurs when there is no enough surfactant in the lungs. Heavy metals are naturally occurring elements that have a high atomic weight and a density at least 5 times greater than that of water. Lead is a heavy metal, it is important environmental toxicant; the toxic effects of lead include many systems in the body like central and peripheral nervous system. Cadmium is heavy metal that exerts toxic effects on the kidney, the skeletal and the respiratory systems, and is classified as a human carcinogen. Nicotine, the main alkaloid of tobacco. It is readily absorbed from tobacco smoke, and its concentration rises over 6-8 hours

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Publication Date
Thu Jul 01 2021
Journal Name
Journal Of Physics: Conference Series
T-Small Quasi-Dedekind modules
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Abstract<p>Let Q be a left Module over a ring with identity ℝ. In this paper, we introduced the concept of T-small Quasi-Dedekind Modules as follows, An R-module Q is T-small quasi-Dedekind Module if, <inline-formula> <tex-math><?CDATA $\forall \,w\,\in En{d}_{R}(Q),\,w\ne 0$?></tex-math> <math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mrow> <mo>∀</mo> <mspace width="0.25em"></mspace> <mi>w</mi> <mspace width="0.25em"></mspace> <mo></mo></mrow></math></inline-formula></p> ... Show More
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Publication Date
Fri May 01 2020
Journal Name
Journal Of Physics: Conference Series
ESSENTIAL T-hollow-lifting module
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Abstract<p>Let M be a R-module, where R be a commutative ring with identity, In this paper, we defined a new kind of module namely ET-hollow lifting module, Let T be a submodule of M, M is called ET-hollow lifting module if for every sub-module H of M with <inline-formula> <tex-math><?CDATA $\frac{M}{H}$?></tex-math> <math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mrow> <mfrac> <mi>M</mi> <mi>H</mi> </mfrac> </mrow> </math></inline-formula></p> ... Show More
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Publication Date
Tue Feb 27 2024
Journal Name
Pharmacia
Association of the rs1801133 and rs1801131 polymorphisms in the MTHFR gene and the adverse drug reaction of methotrexate treatment in a sample of Iraqi rheumatoid arthritis patients
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Background: Methotrexate is one of the mainstays for treating rheumatoid arthritis (RA) with a wide range of adverse drug reactions, however, it’s the relationship between adverse drug reactions and genetic polymorphism remains to be highlighted, and there is a lack of studies concerning Arabic Iraqi population regarding this aspect.

Objective: Evaluate the association between genetic mutations in the MTHFR gene in SNPs (rs1801133G&gt;A and rs1801131T&gt;G) on the adverse drug reaction for RA Iraqi patients.

Methods: An observational study, that involved 95 Iraqi RA patients with established RA. Patien

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Publication Date
Wed Mar 15 2023
Journal Name
Journal Of Survey In Fisheries Sciences
The Correlation of DAZ1 Gene Methylation with Azoospermia in Iraqi Infertile Men
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After about twelve months or maybe more, some people can’t achieve pregnancy. This might be a sign of infertility as a reproductive system disease. The following study was carried out to investigate the DAZ 1 gene methylation level and its association with azoospermia in Iraqi patients. One hundred and fifty human blood samples were collected from from different regions in Baghdad governorate, including (private medicals Labs and the high institute for infertility diagnosis assisted reproductive techniques and Kamal Al- Samara'ay IVF Hospital) from both fertile and infertile men. The control group consists of 50 samples ranging from 22 to 51 years old, while the patient (infertile group) consists of 100 samples ranging between 25 and 51 y

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Publication Date
Tue Jan 01 2019
Journal Name
Technologies And Materials For Renewable Energy, Environment And Sustainability: Tmrees19gr
Theoretical calculations involving a standard neutron yield distribution for the T-T nuclear fusion reaction
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A standard theoretical neutron energy flux distribution is achieved for the triton-triton nuclear fusion reaction in the range of triton energy about ≤10 MeV. This distribution give raises an evidence to provide the global calculations including the characteristics fusion parameters governing the T-T fusion reaction.

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Publication Date
Tue Jul 08 2014
Journal Name
African Journal Of Traditional, Complementary And Alternative Medicines
Hepatoprotective Effect Of &lt;i&gt;Cymbopogon Citratus&lt;/i&gt; Aqueous Extract Against Hydrogen Peroxide-Induced Liver Injury In Male Rats
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Publication Date
Fri Jan 31 2025
Journal Name
Open Veterinary Journal
&lt;b&gt;Histopathological effects of repeated 14-day administration of rizatriptan benzoate in a nitroglycerin-induced migraine rabbit model&lt;/b&gt;
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Background: Migraine is one of multiple attack neurological conditions that causes moderate to severe headaches with no defined pathophysiology and few animal models. Aim: Establishing an animal model that reproduces migraine-like action is important in medical research to identify the mechanism underlying this disorder. Additionally, it facilitates the availability and reliability of new models that may act as human surrogate models. Method: Rabbits were divided into four groups. Negative group, migraine group, rizatriptan- nitroglycerin group, and rizatriptan group. The frequency of head scratching and the histopathological changes in the brain, liver, kidney, and heart for groups were evaluated in all groups. Results: T

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Publication Date
Sun May 01 2011
Journal Name
Information Sciences
Design and implementation of a t-way test data generation strategy with automated execution tool support
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