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Abstract: The article aimed to formulate an MLX binary ethosome hydrogel for topical delivery to
escalate MLX solubility, facilitate dermal permeation, avoid systemic adverse events, and compare
the permeation flux and efficacy with the classical type. MLX ethosomes were prepared using the
hot method according to the Box–Behnken experimental design. The formulation was implemented
according to 16 design formulas with four center points. Independent variables were (soya lecithin,
ethanol, and propylene glycol concentrations) and dependent variables (vesicle size, dispersity
index, encapsulation efficiency, and zeta potential). The design suggested the optimized formula
(MLX−Ethos−OF) with the highest desirability to perform the
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