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Effect of uricol® and food with different samafurantin® doses on secondary pharmacokinetic parameters by applying urinary data
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Introduction: Nitrofurantoin (NFT) is abroad spectrum bactericidal antibiotic. The bioavailability of NFT is affected by many factors. Samafurantin® tablets containing 50 mg NFT were manufactured by Samarra drug industry. Urinary excretion studies were employed since; the urinary tract is the main site of NFT action and excretion. Objective: The objective of the study was to investigate the effect of Uricol® and food on secondary pharmacokinetic parameters of Samafurantin® tablets with different doses by applying urinary data. Methods: Twelve healthy male volunteers participated in this study. Urine samples were collected from each volunteer after overnight fasting at a specified time intervals which considered as a blank sample for measuring urine pH of urine. After that, volunteers were randomly divided into two groups (G1 and G2) each of six. Group 1 was administered 100 mg of NFT (Two tablets of 50 mg Samafurantin®) while, G2 was administered 200 mg of NFT (Four tablets of 50 mg Samafurantin®) as a single oral dose. Both groups administered the dose on an empty stomach (fasting), along with one Uricol® of 5 g sachet on fasting, and on full stomach after eating a standard breakfast after 1-week washout period between each experiment and another. For each experiment, urine samples were collected from each volunteer from 0.25 to 7 h post dosing. In addition, the volume of each void urine sample was measured. Results: Both groups (G1 and G2) showed only slight differences in the pH of urine after administration of Samafurantin® as compared with that of the blank. While, the pH of urine for both groups was higher after administration of Samafurantin® tablets along with Uricol® 5 g. In both groups, each of Uricol® and food exhibited no significant differences (P < 0.05) in secondary pharmacokinetic parameters of NFT; the rate constant of elimination (Kel) and absorption (Ka) and consequently their half-life (t0.5 el and t0.5 abs) as long as the drug followed first-order kinetics. While significant differences (P < 0.05) were observed for maximum excretion rate (ExRmax), cumulative amount excreted in urine (CAe) and CAe as percentage of the dose. This could be attributed to the pH-change of urine by Uricol® which alkalinized the urinary and kidney tract or delaying gastric emptying by food. Same observations were attained when comparing G1 with G2 after administration of NFT on fasting. Conclusions: Administration of Samafurantin® tablets at higher doses, along with Uricol® or with food increases secondary pharmacokinetic parameters related to the rate and extent of absorption and elimination without significant changes in their corresponding rate constants and half-lives. © 2018 Drug Invention Today.

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Publication Date
Thu Nov 01 2012
Journal Name
Journal Of Drugs In Dermatology: Jdd
Treatment of scabies using 8% and 10% topical sulfur ointment in different regimens of application.
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KE Sharquie, JR Al-Rawi, AA Noaimi, HM Al-Hassany, Journal of drugs in dermatology: JDD, 2012 - Cited by 47

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Publication Date
Mon Feb 23 2026
Journal Name
Journal Of Baghdad College Of Dentistry
Evaluation of the relationship between curve of Spee and dentofacial morphology in different skeletal patterns
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Background: Curve of Spee (CS) is an anteroposterior anatomical curve established by the occlusal alignment of the teeth viewed in the sagittal plane. This occlusal curvature has clinical importance in orthodontics and other fields of dentistry. This study aimed to evaluate the relationship between the CS and dentofacial morphology of different skeletal patterns in both genders. Materials and Methods: Eighty six Iraqi Arab subjects (44females,42 males ) their age ranged from 17 -30 years, classified into: Skeletal I with normal occlusion(15 females and 15 males), skeletal II with CI II div 1 malocclusion (15 females and 15 males) and skeletal III with CI III malocclusion (14 females and 12 males). Forty one variables measured us

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Publication Date
Sat Sep 01 2018
Journal Name
Polimery
Synthesis and properties of vinylpyrrolidone/ (trimethoxysilyl)propyl methacrylate gels containing different amounts of crosslinking agent
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Publication Date
Sun Nov 26 2017
Journal Name
Journal Of Engineering
The Dynamic Behavior of Water Flowing Through Packed Bed of Different Particle Shapes and Sizes
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An experimental study was conducted on pressure drop of water flow through vertical cylindrical packed beds in turbulent region and the influence of the operating parameters on its behavior. The bed packing was made of spherical and non-spherical particles (spheres, Rasching rings and intalox saddle) with aspect ratio range 3.46  D/dp  8.486 obtaining bed porosities 0.396 0.84 and Reynolds number 1217  21758. The system is consisted of 5 cm inside diameter Perspex column, 50 cm long; distilled water was pumped through the bed with flow rate 875, 1000, 1125, 1250,1375 and 1500 l/h and inlet water temperature 20, 30, 40 and 50 ˚C. The packed bed system was monitored by using LabVIEW program, were the result

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Publication Date
Tue Oct 01 2013
Journal Name
International Journal Of Biological Macromolecules
Characterization and determination of lignin in different types of Iraqi phoenix date palm pruning woods
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Publication Date
Sun Jun 05 2016
Journal Name
Baghdad Science Journal
Population Density and Susceptibility of Some Varieties of Potato to Infested by Aphid and Thrips on Spring Plantation in the Middle of Iraq
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Aphid Aphis spp (Hemiptera:Aphididae) and Thrips Thrips spp (Thysanoptera: Thripidae) an economically important pests on several crops in the world and Iraq, that transfer many viruses diseases to it. Field studies were conducted to assessment the population density of these insects and susceptibility of six varieties (Barin, Revera, Divela, Rudlph, Alazata and Pleny) to infestation during 2013 spring season. The results were showed that all Potato varieties were infested by Aphis and Thrips on spring plantation but with different percentage. The Divela variety was higher percentage of infestation and high population density of aphid which averaged 1.47 insect/ leaf while in Alazata was the lower population density which averaged 1.02 in

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Publication Date
Sat Dec 01 2018
Journal Name
Al-khwarizmi Engineering Journal
Investigation of Load and Pressure Distribution on Wing with Wake Rollup for Low Speed Aircraft
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The presented work shows a preliminary analytic method for estimation of load and pressure distributions on low speed wings with flow separation and wake rollup phenomena’s. A higher order vortex panel method is coupled with the numerical lifting line theory by means of iterative procedure including models of separation and wake rollup. The computer programs are written in FORTRAN which are stable and efficient.

      The capability of the present method is investigated through a number of test cases with different types of wing sections (NACA 0012 and GA(W)-1) for different aspect ratios and angles of attack, the results include the lift and drag curves, lift and pressure distributions along the wing s

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Publication Date
Wed Aug 30 2023
Journal Name
Baghdad Science Journal
The Influence of Obesity and IL-6 on Infertile Iraqi Women with COVID-19 Complications
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Infertility is one of the types of diseases that occur in the reproductive system. Obesity is a state that can be occurred due to excessive fats, the progression in obesity stage results in a change in adipose tissue and the development of chronic inflammation, endocrine glands disorders and women’s reproductive system, and also increase the infection with covid-19. The study aimed to investigate the effect of the obesity, lipid-profile, and IL-6 on hormones-dysregulation in infertile-women with COVID-19 complications. The current study included 70 samples: 50 infertility-women-with-covid-19-infected, 20 healthy-women/control, the ages of both patients and healthy subjects were selected within the range 18-34 years. Levels of FBS, LH,

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Publication Date
Fri Jun 01 2018
Journal Name
Journal Of Engineering
Experimental Study on Tribological Characteristics of AA 6061 Alloy Reinforced with Al2O3 and B4C Particles
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Two different composite materials were prepared by stir casting method of AA 6061 alloy as a matrix reinforced with two addition different ceramic materials Al2O3 and B4C of grain size   20 µm by 2.5, 5, 7.5 and10% in weight. The composite material with aluminum alloy as a matrix possesses a unique mechanical properties such as: high specific strength and hardness, low density, and high resistance to corrosion and friction wear. This composite is widely used in automotive parts space and marine applications.

Pin-on-disc technique was used to calculate the wear rate for each addition of Al2O3 and B4C particles. Rockwell hardness test and

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Publication Date
Sun Mar 01 2020
Journal Name
Baghdad Science Journal
The Influence of Magnetohydrodynamic Flow and Slip Condition on Generalized Burgers’ Fluid with Fractional Derivative
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This paper investigates the effect of magnetohydrodynamic (MHD) of an incompressible generalized burgers’ fluid including a gradient constant pressure and an exponentially accelerate plate where no slip hypothesis between the burgers’ fluid and an exponential plate is no longer valid. The constitutive relationship can establish of the fluid model process by fractional calculus, by using Laplace and Finite Fourier sine transforms. We obtain a solution for shear stress and velocity distribution. Furthermore, 3D figures are drawn to exhibit the effect of magneto hydrodynamic and different parameters for the velocity distribution.

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