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Evaluation of the protective effect of Omega-7 against Methotrexate Genotoxicity in bone marrow Cells of Mice
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نظرة عامة: تُعرَّف المادة أو العامل الذي يمكن أن يؤثر على الحمض النووي أو الكروموسومات على أنه سم جيني. قد يؤدي تلف الحمض النووي في الخلية الجسدية إلى حدوث طفرة جسدية ، والتي قد تحفز التحول الخبيث ، في حين أن الضرر الذي يلحق بالخلية الجرثومية قد يؤدي إلى تغيير خاصية وراثية (طفرة في السلالة الجرثومية) (سرطان). أحد الأحماض الدهنية الأحادية غير المشبعة الأحادية غير الأساسية هو حمض البالميتوليك. بعد حمض الأوليك وحمض البالمتيك ، يُصنف حاليًا من بين الأحماض الدهنية الحرة غير المشبعة في دم الإنسان. مع تأثير مضاد للالتهابات ومضاد للسمنة ومضاد لمرض السكر الهدف: تقييم التأثير الوقائي المحتمل لأوميغا 7 ضد السمية الجينية التي يسببها الميثوتريكسات. الطريقة: تم تقسيم جميع الفئران السبعين بالتساوي إلى مجموعتين من كل مجموعة تم تكوين خمس مجموعات فرعية. كانت كل مجموعة بها سبعة فئران على النحو التالي المجموعة الأولى: أعطيت البارافين السائل عن طريق الفم لمدة سبعة أيام متتالية المجموعة الثانية: أعطيت البارافين السائل عن طريق الفم لمدة سبعة أيام متتالية ثم في اليوم الثامن ، تم إعطاء جرعة واحدة داخل الصفاق من الميثوتريكسات (20 مجم / كجم). المجموعة الثالثة: أعطيت أوميغا 7 (50 مجم / كجم) عن طريق الفم لمدة سبعة أيام متتالية ثم في اليوم الثامن ، تم إعطاء جرعة واحدة داخل الصفاق من الميثوتريكسات (20 مجم / كجم). المجموعة الرابعة: أعطيت أوميغا 7 (100 مجم / كجم) عن طريق الفم لمدة سبعة أيام متتالية ثم في اليوم الثامن ، تم إعطاء جرعة واحدة داخل الصفاق من الميثوتريكسات (20 مجم / كجم). المجموعةV تعطى أوميغا 7 عن طريق الفم لمدة سبعة أيام بجرعة 100 مجم / كجم: النتائج: عند مقارنتها بفئران المجموعة الأولى الضابطة ، ساهمت المجموعة الثانية في انخفاض كبير (P <0.05) في مؤشر الانقسام الفتيلي ، بالإضافة إلى ارتفاع أسي في مظهر النواة الدقيقة وإجمالي الانحرافات الصبغية ؛ ومع ذلك ، قللت المجموعتان الرابعة والخامسة من انحراف الكروموسومات ، وظهور النواة الصغيرة ، وارتفاع مؤشر الانقسام. مقارنة بفئران المجموعة الثانية المعالجة بالميثوتريكسات. الخلاصة: من المعروف أن الميثوتريكسات يسبب تأثيرات سامة للجينات ، وقد ثبت أن أوميغا 7 لها دور وقائي ضد ذلك. المصطلحات: ميثوتريكسات ، أوميغا 7 ، انحراف الكروموسومات ، مظهر النواة الصغيرة ، مؤشر الانقسام          

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Wed Jul 01 2020
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Biochemical And Cellular Archives
Histopathological changes in liver induced by piroxicam administration in adult male albino mice mus musculus
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Publication Date
Mon May 16 2022
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International Journal Of Biomaterials
Histopathological and Biochemical Comparative Study of Copper Oxide Nanoparticles and Copper Sulphate Toxicity in Male Albino Mice Reproductive System
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Copper (Cu) is an essential trace element for the efficient functioning of living organisms. Cu can enter the body in different ways, and when it surpasses the range of biological tolerance, it can have negative consequences. The use of different nanoparticles, especially metal oxide nanoparticles, is increasingly being expanded in the fields of industry and biomedical materials. However, the impact of these nanoparticles on human health is still not completely elucidated. This comparative study was conducted to evaluate the impacts of copper oxide nanoparticles (CuO NPs) and copper sulphate (CuSO4 0.5 (H2O)) on infertility and reproductive function in male albino mice BALB/c. Body weight, the weight of male reproductive organs, mal

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Publication Date
Sun Jan 01 2012
Journal Name
Advances In Materials Physics And Chemistry
The Effect of Zn Concentration on the Optical Properties of Cd&amp;lt;sub&amp;gt;10–x&amp;lt;/sub&amp;gt;Zn&amp;lt;sub&amp;gt;x&amp;lt;/sub&amp;gt;S Films for Solar Cells Applications
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Tue Dec 30 2025
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حوليات أداب عين شمس
Evaluation of Groundwater Suitability in Ain Tamr District in Iraq
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Publication Date
Mon Jul 13 2026
Journal Name
Research Journal Of Pharmacy And Technology
Ex vivo study of anti-leishmanial activity of artemisinin against Leishmania tropica amastigote
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Leishmania parasites are the causative agent of leishmaniasis. Many studies are inspecting chemical drugs, including the use of miltefosine and amphotericin B, but curative values may be limited for these drugs with side effects due to the chemical origin, therefore, investigating less toxic therapies is essential. The aim of this study was to investigate the effectiveness of artemisinin on Iraqi strain of Leishmania tropica, by experimental macrophage ex vivo infection of amastigotes into mouse macrophage cell-line RAW264.7. Different concentrations (100, 200, 300, 400, 500)μM of artemisinin (ART) were screened to examine the susceptibility of L. tropica amastigotes to invade macrophage cell line along three times of follow up (24, 48 and

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Publication Date
Thu Oct 01 2020
Journal Name
Systematic Reviews In Pharmacy
Estimation of activity and toxicity of silver nanoparticles loaded metronidazole against Giardia lamblia
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Giardia lamblia is one of most common protozoan cause diarrheas, and the most health problem in development countries worldwide. Our work aimed to assess activity and toxicity of metronidazole loaded silver nanoparticles in treatment of acute giardiasis in mice. After inoculated mice with Giardia cysts in a dose of 105 cyst for acute infection, treatments were given for eight days. Number Giardia cysts in stool were discovered. Toxicity nanoparticles was estimated by Measurement oxidative stress markers (GSH) and (MDA) in liver, kidney tissue homogenate. The results showed single therapy was better effect by silver nanoparticles, highest percentages of reduction in number of cysts Giardia lamblia of infected mice treated with silver nanopar

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Publication Date
Thu Dec 15 2022
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Bionatura
Antibiogram of Eucalyptus and Sesame seed oil against clinical isolates of Pseudomonas aeruginosa
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Publication Date
Sun Jun 06 2010
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Baghdad Science Journal
Antibacterial Activities of Volatile oils from mentha Piperia Against Growth of Pathogenic Bacteria
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The study included the extraction of volatile oil from Mentha piperita which was 1.3 % in the leaves and flowers . Volatile oil of the Mentha piperita leaves had special aromatic odour, pale yellow color, slightly pungent taste . The specific gravity and refractive index were (0.9794) and ( 1.464) respectively. The inhibition activity of the Mentha piperita Volatile oil extracts were studied on some pathogenic microorganisms like Staphylococcus aureus, Salmonella typhi, Escherichia coli, Proteus sp, and Klebsiella pneumoniae . The result showed that the volatile oil had an inhibition effect on the growth of all microorganisms, and it gave the higher inhibition effect on the growth of S. aureus in which the inhibition zone reached to 2

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Crossref (1)
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Publication Date
Wed Sep 16 2020
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Research Journal Of Pharmacy And Technology
Ex vivo study of anti-leishmanial activity of artemisinin against Leishmania tropica amastigote
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Leishmania parasites are the causative agent of leishmaniasis. Many studies are inspecting chemical drugs, including the use of miltefosine and amphotericin B, but curative values may be limited for these drugs with side effects due to the chemical origin, therefore, investigating less toxic therapies is essential. The aim of this study was to investigate the effectiveness of artemisinin on Iraqi strain of Leishmania tropica, by experimental macrophage ex vivo infection of amastigotes into mouse macrophage cell-line RAW264.7. Different concentrations (100, 200, 300, 400, 500)μM of artemisinin (ART) were screened to examine the susceptibility of L. tropica amastigotes to invade macrophage cell line along three times of follow up (24, 48 and

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Scopus
Publication Date
Mon Nov 01 2021
Journal Name
Journal Of Physics: Conference Series
Neural Network Model for Synthesis of Thermally Sprayed (AI/AI<sub>2</sub>O<sub>3</sub>) Composite Protective Coatings
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Abstract<p>Al<sub>2</sub>O<sub>3</sub> and Al<sub>2</sub>O<sub>3</sub>–Al composite coatings were deposited on steel specimens using Oxy-acetylene gas thermal spray gun. Alumina was mixed with Aluminum in six groups of concentrations (0, 5, 10,12,15 and 20% ) Al2O3, Specimens were tested for corrosion using Potentiodynamic polarization technique. Further tests were conducted for the effect of temperature on polarization curve and the hardness tests for the coated specimens. At first, Modelling was carried out using MINITAB-19, least square method, as a 2nd degree nonlinear model, bad results were achieved because of the high nonlinearity. Better result w</p> ... Show More
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