Lasmiditan (LAS) was formulated as a nanoemulsion based in situ gel (NEIG)with the aim of improving its oral bioavailability via application intranasally. The solubility of LAS in oils, emulsifiers, and co-emulsifiers was determined to identify nanoemulsion (NE)components. Phase diagrams were constructed to identify the area of nanoemulsification. LAS NE was formulated using the spontaneous nanoemulsification method. Four NEs (F19, F24, F31, and F34) containing 7-15 % oleic acid (OA) as an oily phase, 40-55% labrasol (LR), and transcutol (TC) as emulsifier mixture at (1:1), (2:1), (3:1), and (1:2) ratio with 30-53 % (w/w) aqueous phase, having suitable optical transparency of 95–98%, globule size of 104-140 nm and polydispersity of 0.253–0.382 were selected for ex vivo permeation study. F31 with the highest flux value (2.32 ± 0.01 mg/cm2.min) relative to the other NEs. It achieves an enhancement ratio of 3.3 as compared to LAS aqueous suspension (8% LAS) also it achieves a significantly higher value of permeability coefficient. F31 was selected for the incorporation of different percentages of pH-sensitive in situ gelling polymer (Carbopol 934) to prepare NEIGs 4,5 and 6. The gel strength, pH, gelation time, and viscosity were predicted for the prepared NEIGs. In vitro release and ex vivo, nasal permeation were determined for NEIG5, which exerts comparable release and permeation values as F31 with more residence time in order to overcome the normal nasal physiological clearance.
The present work covers the analytical design process of three dimensional (3-D) hip joint prosthesis with numerical fatigue stress analysis. The analytical generation equations describing the different stem constructive parts (ball, neck, tour, cone, lower ball) have been presented to reform the stem model in a mathematical feature. The generated surface has been introduced to FE solver (Ansys version 11) in order to simulate the induced dynamic stresses and investigate the effect of every design parameter (ball radius, angle of neck, radius of neck, neck ratio, main tour radius, and outer tour radius) on the max. equivalent stresses for hip prosthesis made from titanium alloy. The dynamic loading case has been studied to a stumbling ca
... Show MoreIn this paper we introduce the basic of definitions of groups for geometric figures; we describe some of geometric figures by using the properties of groups. The classification of some geometric figures by using the properties of some algebraic structures.
In this paper we define and study new generalizations of continuous functions namely, -weakly (resp., w-closure, w-strongly) continuous and the main properties are studies: (a) If f : X®Y is w-weakly (resp., w-closure, w-strongly) continuous, then for any AÌX and any BÌY the restrictions fïA : A®Y and fB : f -1(B)®B are w-weakly (resp., w-closure, w-strongly) continuous. (b) Comparison between deferent forms of generalizations of continuous functions. (c) Relationship between compositions of deferent forms of generalizations of continuous functions. Moreover, we expanded the above generalizations and namely almost w-weakly (resp., w-closure, w-strongly) continuous functions and we state and prove several results concerning it.
The research is concerned with the problems of knowledge purification of kindergarten children by verifying its aims, identifying of knowledge purification among the first level of kindergarten children and the second level of kindergarten children, and the differences between the males and females in the variable of knowledge purification. The research community included the children in the state and private kindergartens in Baghdad governorate, on its two sides, Karkh and Rusafa, for the six districts for the academic year 2022-2023. After making the knowledge purification test according to the scientific steps of test constructions, the test has been presented to a group of experts specialized in the field of kindergarten to ascertain
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Insulin resistance is a fundamental feature of obesity, diabetes, and cardiovascular diseases and contributes to many of the metabolic syndrome's abnormalities. It is defined as a subnormal reaction to normal insulin concentrations or a situation in which greater than normal insulin concentrations are necessary for normal response.
The researcher found that neglecting our Arab Islamic heritage and bragging about what the West came in the field of education and psychology is common in our curriculum
So the researcher found it necessary to identify the thought of our media Arab Muslims like Ibn Al-Jawzi being a remarkable figure in the world of human thought therefore, the researcher in this research decided to identify his educational and psychological ideas and psychological emotions in his mind and methods of control and characteristics of the human soul and methods of development of the Muslim character by following the descriptive analytical approach.
Borrowing in linguistics refers to the process whereby a group of speakers incorporates certain foreign linguistic components into their home language via a process known as linguistic borrowing. The process by which these foreign linguistic elements, known as loanwords, go through phonological, morphological, or semantic changes in order for them to fit the grammar of the recipient language is referred to as loanword adaptation. Loanwords go through these changes in order for them to become compatible with the grammar of the recipient language. One of the most divisive topics in loanword phonology is whether adaptations occur at the phonemic or phonetic levels, and current literature distinguishes three primary viewpoints: nativiza
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