CD40 Gene Variants and Disease Susceptibility: A Comprehensive Review of Associations with Immune-Mediated Inflammatory Diseases, Cancer, and Infectious Diseases

Aisha Muthanna Shanshal; Samer Imad Mohammed; Bassam Francis  Matti

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Publication Date

Sun Apr 27 2025

Journal Name

Al-rafidain Journal Of Medical Sciences ( Issn 2789-3219 )

Volume

8

Issue Number

2

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CD40 Gene Variants and Disease Susceptibility: A Comprehensive Review of Associations with Immune-Mediated Inflammatory Diseases, Cancer, and Infectious Diseases

CD40

Case control

Immune disease

Polymorphism

Aisha Muthanna Shanshal

Samer Imad Mohammed

Bassam Francis Matti

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CD40 is a type 1 transmembrane protein composed of 277 amino acids, and it belongs to the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in a variety of cell types, including normal B cells, macrophages, dendritic cells, and endothelial cells, as a costimulatory molecule. This study aims to summarize the CD40 polymorphism effect and its susceptibility to immune-related disorders. The CD40 gene polymorphisms showed a significant association with different immune-related disorders and act as a risk factor for increased susceptibility to these diseases.

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Publication Date

Mon Jul 01 2024

Journal Name

Journal Of The Faculty Of Medicine Baghdad

The Burden of Chronic Obstructive Pulmonary Disease COPD in Stable Patients and its Association with Inflammatory Biomarkers and Body Mass Index

Disease burden

COPD

productivity

tumor necrosis factor-α

interleukin- 6.

Samaa D.

Ali L.

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Background: Chronic obstructive pulmonary disease (COPD) is a progressive airflow limitation that is preventable but not curable. It is associated with persistent symptoms that cause a considerable burden on individual productivity at work, and daily activities, and reduced quality of life, also burdening the healthcare system and society. Objectives: The study aims to measure the burden of COPD on patients in terms of daily activities and work productivity. It also seeks to investigate some inflammatory biomarkers' levels and their correlation with selected outcomes. Patients and Methods: A cross-sectional study on 120 stable COPD patients who were diagnosed and treated according to the GOLD guidelines at Kirkuk General Hospital's

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Publication Date

Thu Jun 01 2023

Journal Name

Cellular, Molecular And Biomedical Reports

Comprehensive analysis of microRNA (miRNA) in cancer cells

Naghmana

Othman

Haider Majid Haider

Ali

Mohammad

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(28)

Publication Date

Thu Jun 25 2020

Journal Name

Scientific Reports

Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS

LPCAT2

LPS

LPCAT1

TLR4

TLR2

siRNA

shRNA

macrophage

cytokine

gene expression

W.

H.

M.

A. J.

S. K.

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Despite extensive investigations, an effective treatment for sepsis remains elusive and a better understanding of the inflammatory response to infection is required to identify potential new targets for therapy. In this study we have used RNAi technology to show, for the first time, that the inducible lysophosphatidylcholine acyltransferase 2 (LPCAT2) plays a key role in macrophage inflammatory gene expression in response to stimulation with bacterial ligands. Using siRNA- or shRNA-mediated knockdown, we demonstrate that, in contrast to the constitutive LPCAT1, LPCAT2 is required for macrophage cytokine gene expression and release in response to TLR4 and TLR2 ligand stimulation but not for TLR-independent stimuli. In addition, cells transfe

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(26)

(33)

Publication Date

Thu Feb 01 2024

Journal Name

Biologicals

Adjuvant effects of novel water/oil emulsion formulations on immune responses against infectious bronchitis (IB) vaccine in mice

Karar Ali Mohammed Hasan

Furkan Ozan

Ayse

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(3)

(2)

Publication Date

Wed Aug 31 2022

Journal Name

Al-kindy College Medical Journal

Acute Appendicitis and Multisystemic Inflammatory Syndrome due to COVID-19: a Case Report and Literature Review

Pandemic

COVID19

MIS

Appendicitis

Abdominal pain

M.

R. M.

R.Q

B.M.

A.Y

Afnan Waleed

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The prevalence of gastrointestinal symptoms of COVID-19 is variable with different types of presentations. Some of them many present with manifestations mimicking surgical emergencies. Yet, the pathophysiology of acute abdomen in the context of COVID-19 remains unclear. We present a case of a previously healthy child who presented with acute appendicitis with multisystemic inflammatory syndrome. We also highlight the necessity of considering the gastrointestinal symptoms of COVID-19 infection in pediatric patients in order to avoid misdiagnosis and further complications.

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Publication Date

Wed Apr 03 2013

Journal Name

Iraqi Journal Of Medical Sciences

Ligasure versus clamp and tie technique to achieve henostasis in thyroidectomy for benign diseases

Prof Dr Basim

Asst. prof. Tariq Ibrahim Al-Aubaidi

Dr. Muayad Abass Fadhel

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Publication Date

Sun Jan 01 2023

Journal Name

Revista Brasileira De Enfermagem

Healthy lifestyle behaviors and risk of cardiovascular diseases among nursing faculty during COVID-19 Pandemic

Ayad Majid Mousa

Mohammed Baqer

Sabah A

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ABSTRACT Objective: Cardiovascular diseases are the first ranked cause of death worldwide. Adhering to health promoting lifestyle behaviors will maintain an individual’s cardiovascular health and decrease the risk of cardiovascular diseases. Methods: In this descriptive study, 150 nursing faculty were surveyed via a non-probability (purposive) sampling method to assess their adherence to health promoting lifestyle in order to know the risk of cardiovascular diseases. The Arabic version of Health-Promoting Lifestyle Profile II (HPLP-II) was used to achieve this goal. Results: Seventy-two nursing faculty completed the survey. The results indicated that the study sample had moderate level of health promotion based on Health-Promot

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(8)

(1)

Publication Date

Mon Jun 30 2014

Journal Name

Al-kindy College Medical Journal

The Role of Interleukine-33 in Inflammatory Bowel Disease

Inflammatory bowel disease

IL-33

Ulcerative colitis.

Raghad R.

Ahmed A.

Khalid A.

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The inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are heterogenous chronic inflammatory disorders of the gastrointestinal tract. The most widely accepted etiopathogenic hypothesis for these disorders suggests an immune mediated process.
Objective: This study was performed to evaluate the role of interleukine-33 in pathogenesis of inflammatory bowel disease and to correlate their levels with the disease activity and/or severity.
Methods: Fifty five subjects with inflammatory bowel disease (41 ulcerative colitis patients and 14 Crohn’s disease patients) their ages range from 16-65 years and 25 apparently healthy volunteers their ages and sexes were matched with the patients were participated i

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Publication Date

Sat Jan 01 2022

Journal Name

Malaysian Journal Of Medicine And Health Sciences

Severity of Coronavirus Disease 19: A Profile of Inflammatory Markers in Iraqi Patients

Rasha M.A.

Hanan Y. Muhsin

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(10)

Publication Date

Sun Nov 01 2020

Journal Name

Am J Clin Res Rev

Clinical and histopathological findings in patients with follicular dermatoses: all skin diseases starts in the hair follicles as new hypothesis

AA Noaimi

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KE Sharquie, AA Noaimi, RA Flayih, Am J Clin Res Rev, 2020 - Cited by 4

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