Silymarin is derived from the milk thistle plant, and possesses numerous pharmacological actions, including hepatoprotective, anti-inflammatory, antioxidant, and anticancer properties. The aim of the study was to the determination of influence different concentrations of Silymarin on the rumen performance in 30 local lambs (divided into three groups of 10 lambs each). In the first and second groups, 420 and 210 mg kg-1 of silymarin were administered for 8 weeks, and the third group was the control, which received normal saline solution. The parameters evaluated included the level of volatile fatty acids (VFAs), ammonia and pH in the rumen. Furthermore, the in vitro digestibility of ash, protein, fat and dry matter was investigated. These parameters were examined fortnightly, for eight weeks. The results showed that the level of volatile fatty acids and pH increased in the rumen in G1 and G2 compared to the control group, while the level of ammonia decreased in the rumen in G1 and G2 when compared to G3 (p<0.05). Silymarin increased the in vitro digestibility of crude ash (CA), crude protein (CP), crude fat (CF) and crude dry matter (CDM) in the rumen of lambs. These results indicate that silymarin can improve the digestibility of nutrient elements in the lamb rumen. Keywords: ammonia; digestibility; crude ash; crude protein; crude fat. Concentrações de silimarina nas atividades ruminais de cordeiros RESUMO: A silimarina é derivada da planta do cardo mariano e possui inúmeras ações farmacológicas, incluindo propriedades hepatoprotetoras, anti-inflamatórias, antioxidantes e anticancerígenas. O objetivo do estudo foi determinar a influência de diferentes concentrações de silimarina no desempenho ruminal de 30 cordeiros locais, divididos em três grupos (de 10 cordeiros cada). No primeiro e segundo grupo foi administrado 420 e 210 mg kg-1 de silimarina durante 8 semanas, e, o terceiro grupo foi o controle, que recebeu solução salina normal. Os parâmetros avaliados incluíram o nível de ácidos graxos voláteis (AGVs), amônia e pH no rúmen. Além disso, investigou-se a digestibilidade in vitro de cinzas, proteínas, gorduras e matéria seca. Esses parâmetros foram examinados quinzenalmente, durante oito semanas. Os resultados mostraram que o nível de ácidos graxos voláteis e pH aumentaram no rúmen em G1 e G2, em comparação com o grupo controle, enquanto, o nível de amônia diminuiu no rúmen em G1 e G2 quando comparado com G3 (p<0,05). A silimarina aumentou a digestibilidade in vitro da cinza bruta (CA), proteína bruta (PB), gordura bruta (CF) e matéria seca bruta (CDM) no rúmen dos cordeiros. Esses resultados indicam que silimarina pode melhorar a digestibilidade dos elementos nutrientes no rúmen do cordeiro. Palavras-chave: amônia; digestibilidade; cinza bruta; proteína bruta; gordura bruta.
Current research included preparation, characterization of some new chitosan- hydroxy benzaldehyde-Schiff bases with maleic anhydride. The present study aimed to the synthesis and characterization of novel chitosan Schiff base compounds using para- hydroxy benzaldeh and maleic anhydride. The derivative of the schiff-chitosan base, which is associated with different drugs, has been replaced with different amino and hydroxy drugs. The derivative is characterized by different analytical techniques. The results of FT-IR studies clearly indicate construction of the chief amine group in chitosan and the emergence of new bands that correspond to the association of maleic anhydride with the chitosan base. TGA, 1
... Show MoreJumping ability is a fundamental variable in many sports, as its execution requires an integration of muscular strength Q1 and certain biomechanical variables. This is particularly evident in gymnastics jumping events and jump shots in ball games, both of which rely on a high level of vertical resistance. Vertical resistance serves as an indicator of an athlete’s ability to overcome their body weight while counteracting gravitational force to achieve optimal performance. As such, it is considered one of the key factors in movements that demand explosive power and speed. The researchers believe that despite the significant relationship between vertical resistance, speed-strength of the arms and legs, and certain biomechanical varia
... Show MoreThis study investigated the bioethanol production from green algae Chlorella vulgaris depending on its carbohydrate-enriched biomass. Four different phosphorous concentrations were employed to stimulate bioethanol production from Chlorella vulgaris. The impact of various phosphorous values on Chlorella vulgaris growth rate as well as primary product (carbohydrate) were evaluated. High performance liquid chromatography was utilized in this work. The stationary phase was identified as day 14, 12, 10 and 6 in treatments 6, 4, 2 and g/L, respectively. The findings suggest that the treatment without phosphorous addition had the highest record of carbohydrate content (22.64% dry weight) as well as the highest bioethanol yield (20.66% dry weight).
... Show MoreIsatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations c
... Show MoreIsatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations c
... Show MoreThis investigation was carried out to estimate the antiparasitic potential of chitosan nanoparticles loaded with paromomycin against
A new Schiff base of HL has been synthesized from amoxicillin drug and 4- Chlorobenzophenone. Cr (III), Fe (III), Co (II), Ni (II), Cu (II), Cd (II) and Hg (II) mixed ligands complexes of Schiff base and Nicotinamide. Diagnosis of synthesis ligand and its complexes are done by 1HNMR, 13CNMR and thermal analysis for HL ligand, FTIR, UV-visible, molar conductance, CHN analysis, magnetic susceptility and atomic absorption. Octahedral geometries have been suggested for all complexes. All compounds under study were tested antimicrobial activity against four type of bacteria such as Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus Bacillis subtilis in nutrient agar.
Antiviral medications may be the best choices for COVID-19 treatment until particular therapeutic treatments become available. Tamiflu (oseltamivir) is a neuraminidase inhibitor licensed for the management and defense against influenza types A and B. Oseltamivir-based medication combinations are currently being used to treat COVID-19 patients who also have the new coronavirus 1 SARS-CoV-2. 1 Oseltamivir administration was related with a less time spent in the hospital, quicker recovery 1 and discharge, and a decreased mortality rate. Docking is a modern computational method for identifying a hit molecule by assessing the binding ability of molecular medicines within the binding target pocket. In this work, we chose 21 ligand compounds that
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