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To study the qualitative changes in testis tissue after
carbon tetrachloride (CCl4) administration and to determine whether
citric acid (CA) has a protective effect against testis damage induced
by CCl4. This study compared two types of CA by measuring the
histoarchitecture of the testis and serum levels of progesterone,
estrogen and testosterone on mice. One of the most produced organic
acid is citric acid. In this study, CA produced by microbial
fermentation using Aspergillus Niger 5mg/kg and derived from citrus
limon 400mg/kg (lemon). Mice were treated with daily
intraperitoneal (i.p.) injection for seven successive days after
randomly separated into six groups: (1) control, (2) CCl4 (0.02%),
(3) limon citric acid (400 mg/kg), (4) CCl4 (
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