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Ibn AL-Haitham Journal For Pure and Applied Sciences College of Education for Pure Science / Ibn AL-Haitham
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ISSN: 1609-4042
eISSN: 2521-3407
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No. of publications: 2219
No. of views: 1889928
No. of Crossref citations: 722
Publication Date
Thu Mar 16 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Synthesis and Characterization of Schiff Base Folic Acid Based Ligand and Its Complexes
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       D-mannose sugar was used to prepare [benzoic acid 6-formyl-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl ester] (compound A). The condensation reaction of folic acid with (compound A) resulted in the formation of new ligand [L]. These compounds were characterized by elemental analysis CHN, atomic absorption A.A, (FT-I.R.), (U.V.-Vis), TLC, E.S. mass (for electrospray), molar conductance, and melting point. The new tetradentate ligand [L], reacted with two moles of some selected metal ions and two moles of (2-aminophenol), (metal : ligand : 2-aminophenol) at reflux in water medium to give a series of  new complexes of the general formula K2[M2(L)(HA)2]  where M= Co(II), Ni(II), Cu(II) an

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Publication Date
Thu Mar 16 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Adsorption Kinetic and Thermodynamic Study of Congo Red Dye on Synthetic Zeolite and Modified Synthetic Zeolite
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   Linde Type-A (LTA) zeolite was modified by adding  lead sulfide into cavities of zeolite. The zeolite and zeolite –pbs  were characterized by FTIR, XRD, AFM and SEM. The adsorption of congo red (CR)  dye  from aqueous solution by zeolite and zeolite – pbs were studied. Different parameters like contact time, temperature and concentration of (CR) dye were investigated. The results show that at contact time of 45, 30 min for maximum adsorption of (CR) dye onto zeolite and zeolite -pbs respectively were observed. The kinetic data was analyzed using pseudo-first-order and pseudo-second-order kinetic models. The adsorption kinetics of (CR) dye  were fitted well with the pseudo-second-order k

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Publication Date
Thu Mar 16 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Synthesis and Characterization of Some Metal Complexes of [N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol4-ylcarbamothioyl) acetamide]
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   A new  ligand  [N- (1,5- dimethyl -3- oxo- 2 – phenyl - 2 ,3 – dihydro -1H- pyrazol -4ylcarbamothioyl) acetamide] (AAD) was synthesized by reaction of acetyl isothiocyanate with 4-aminoantipyrine, The ligand was characterized by micro elemental analysis C.H.N.S., FT-IR ,UV-Vis and 1H-13CNMR spectra, some transition metals complex of this ligand were prepared and  characterized by FT-IR, UV-Vis spectra, conductivity measurements, magnetic susceptibility and atomic absorption. From the obtained results the molecular formula of all prepared complexes were [M(AAD)2(H2O)2]Cl2  (M+2 = Mn, Co, Ni, Cu, Zn, Cd and Hg),the proposed geometrical structure for all complexes were octahedral.

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Publication Date
Sun Apr 09 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Study the Contrast of Thermal Expansion Behavior of the Unsaturated Polyester resin (UP) containing Phenolic Bakelite(PF) By Using The Thermomechanical Analysis Technique(TMA)
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TMA Technique was used to study the behavior of the thermal expansion (α) of the unsaturated polyester resin(UP) containing ratios wt % of different phenolic Bakelite. We can through this technique evaluate the coefficient of linear thermal expansion (α) on the one hand and the glass transition temperature(Tg)  of his other hand of polymer composite prepared .Evidenced from this study that extravagant increases the ratio of phenolic Bakelite in polyester prepared led to a decrease in the Tg and it was observed that there is increase in the values of (α) in low temperture and decrease in high temperture due to transformation of polymeric material from elastic to plastic , and therefore, increase the ratio to 15% phenoli

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Publication Date
Thu Mar 16 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Kinetic Study of the Effect of Some Novel Lipid Lowering Compounds on Activities of Creatine Kinase and 3Hydroxy-3-Methyl-Glutaryl-CoA Reductase In Mice Induced Hyperlipidemia
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Hyperlipidemia is one of the most important factors leading to atherosclerosis and heart disease, therefore, this study conducted to examine the effect of two newly synthesized compounds[3-(5(ethylthio)-1,3,4-thiadiazol-2-yl)-2,3-dihydro-2-(3-nitrophenyl)benzo[1-3-e] thiazin-4-one (I) and 5(4dimethyl amino) benzylidene amino)-1,3,4-thiadiazole-2-thiol(II)] on the activities of creatine kinase(CK) and 3-hydroxy-3-methylglutaryl- CoA reductase (HMGR) in male Wister mice . Also to determine the type of inhibition of these compounds on the above enzymes .The study was carried out on sixty male Wister mice aged seven to eight weeks their weight ranged(180-200 g) . The mice were grouped as: group(1): control group (12 mice).Group(2):consisted

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Publication Date
Sat Mar 18 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Effect of microwave rays on nymphs of Green Peach : ) (Homoptera1776(Sulzer)( Myzus persicae Aphids Aphididae)
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The research was conducted to study the effect of five exposure periods of microwave radiation (0,10,30,60 and 90) seconds on Nymph of the Green Peach Aphids Myzus persicae by counting the percentage of occured deformation ,rate of mortality percentage and emerged adults percentage, The study showed that the microwave radiation had a great effect on occurring deformation especially at the period 90 seconds, the exposure periods effect on the mortality percentage had a clear affect where the highest percentage of nymphs mortality was ( 52) for exposure period 90 seconds while it was found that the mortality was decreased to 48 and 24 for exposure periods 60 , 30 seconds which was significantly different in comparing with the control . The

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Publication Date
Mon Apr 24 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Estimate the Parameters and Related Probability Functions for Data of the Patients of Lymph Glands Cancer via Birnbaum-Saunders Model
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 In this paper,we estimate the parameters and related probability functions, survival function, cumulative distribution function , hazard function(failure rate) and failure  (death) probability function(pdf) for two parameters Birnbaum-Saunders distribution which is fitting the complete data for the patients of  lymph glands cancer. Estimating the parameters (shape and scale) using (maximum likelihood , regression quantile and shrinkage) methods and then compute the value of mentioned related probability  functions depending on sample from real data which describe the duration of survivor for patients who suffer from the lymph glands cancer based on diagnosis of disease or the inter of patients in a hospital for perio

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Publication Date
Sun Apr 09 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Crystal Growth of Ceasium Hydrogen Sulfate Salts 4CsHSO
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Single crystal of CsHSO4 component was grown by slow evaporation method of aqueous solution with normality N=1 . The study shows that the importance of the process of Recrystal growth of CsHSO4 crystals. The results show the improve of the characteristics of crystals (transparent, size, shape, number and quality) . By X-Ray diffraction, the crystal structure of these crystals have been confirmed by measurement constants of unit cell of crystal lattice. The vibration modes of crystals were studied by FTIR (Fourier Transform Infrared) technique. Finally, achieving the study of microstructure of crystals by polarization of microscopy that is supported with hot stage at different temperatures. The changes occur on these crystals by changing

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Publication Date
Thu Mar 16 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Effect of Annealing Temperature and Thickness on the Structural and Optical Properties of CdSeThin Films
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CdSe alloy has been prepared successfully from its high purity elements. Thin films of this alloy with different thicknesses (300,700)nm have been grown on glass substrates at room temperature under very low pressure (10-5)Torr with rate of deposition (1.7)nm/sec by thermal evaporation technique, after that these thin films have been heat treated under low pressure (10-2)Torr at (473,673)K for one hour. X-ray patterns showed that both CdSe alloy and thin films are polycrystalline and have the hexagonal structure with preferential orientation in the [100] and [002] direction respectively. The optical measurements indicated that CdSe thin films have allowed direct optical energy band gap, and it increases from (1.771.84) eV and from (1.6-1

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Publication Date
Wed Apr 19 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Effect of Aqueous Extract and Essential Oils of the Leaves of Eucalyptus incrassate on β- Lactam Resistant Staphylococcus aureus
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According to the extraction procedure , Eucalyptus incrassata leave sample yielded 5% and 2% w/w(Based on dry leaves ) of the aqueous extract and essential oils respectively. Disk diffusion method was used to determine the antimicrobial activity of aqueous extract and essential oils of E . incrassata leaves against eight isolates of multidrug- resistant of Staphylococcus aureus ( S. aureus) . It was found that aqueous extract and essential oils have variable antimicrobial activity(the inhibition zone diameter ranged from 7 to 14 mm respectively ) , while essential oils showed more effect than aqueous extract .         It was noticed that values of Minimal Inhibitory Concentration ( MIC )  for

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Publication Date
Mon Apr 24 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Synthesis and Characterization of Heterocyclic Compounds Derived From 4- Hydroxy and 4-Amino Acetophenone
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 Two series of Schiff Bases [VI]n and thiazolidin-4-one derivatives[VII]n were synthesized by many steps starting from cyclization of 4- hydroxyacetophenon with thiourea in iodine to yield 1,3-thiazole compound which was reacted with pentoxy bromide in anhydrous potassium carbonate to converted compound[II] and this reacted with Phenol to yield azo compound[III]. The azo compound reacted with ethyl chloro acetate in basic medium to get a new easter compound[IV]  which is converted to their acid hydrazid[V]. The later compound condensation with n-alkoxy benzaldehyde to give new Schiff bases[VI]n . Imine group undergoes addition cyclization with thioglycolic acid to get thiazolidinone compounds[VII]n .Also, two new series of Schi

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Publication Date
Sat Mar 18 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Effect of Annealing on The Structural and Optical Properties of SnS Thin Films
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 Thin  films   of  pure   tin mono-sulfide  SnS with thicknesses of   (0.85) μm  were prepared by chemical spray  pyrolysis  technique  and  annealed for  two  hours with 673K.The effect of annealing on structural and optical properties for films prepared was  studied.  X-Ray   diffraction  analysis  showed   the  polycrystalline  with   orthorhombic structure.  It was  found  that   annealing process increased the intensity of diffraction peaks. Optical   properties  of  all  samples  were studied by  recording  the  absorption  and  transmission &nbsp

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Publication Date
Sat Mar 18 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Design of Electrostatic immersion Lens Accelerating Operated Under Zero Magnification Conditions
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 Theoretical study computerized has been carried out in electron optics field, to design electrostatic immersion lens , the inverse problem is important method in the design of electrostatic lenses by suggesting an axial electrostatic potential distribution using polynomial function. The paraxial –ray equation is solved to obtain the trajectory particles that satisfy the suggested potential function. In this research, designed immersed lens length L = 10mm operated under zero condition, as it was obtained the electrode shape of this lens solutions using the Laplace equation The results of the search showed low values of spherical and chromatic aberrations, which gives a good indication of the design of the lens.   It was

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Publication Date
Fri Oct 20 2023
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Quasi-semiprime Modules
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    Suppose that A be an abelain ring with identity, B be a unitary (left) A-module, in this paper ,we introduce a type of modules ,namely Quasi-semiprime A-module, whenever   is a Prime Ideal For proper submodule N of  B,then B is called Quasi-semiprime module ,which is a Generalization of Quasi-Prime A-module,whenever  annAN is a prime ideal for proper submodule N of B,then B is Quasi-prime module .A comprchensive study of these modules is given,and we study the Relationship between quasi-semiprime module and quasi-prime .We put the codition coprime over cosemiprime ring for the two cocept quasi-prime module and quasi-semiprime module are equavelant.and the cocept of  prime module and quasi

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Publication Date
Sun Apr 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Estimating the Effectiveness of Pfizer and Sinopharm Vaccines and their Relationship to Occupation, Residence, Smoking, and Body Mass Index During Pregnancy Smoking
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a rapid global demand for the development of several vaccines by the scientific community. Vaccination contributes to preventing infection associated with symptoms and reduces the risk of infection by stimulating the immune system to produce antibodies. This study aimed to determine the effectiveness of Pfizer and Sinopharm vaccines and their relationship to occupation, residence, pregnancy, mass index, and smoking. This study was conducted in Diyala Province, Iraq, for the period from April 2022 to May 2023. A total of 266 blood samples were collected. Written consent was obtained by the Research Ethics Committee in the Diyala Health Department(DHD/No-

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Publication Date
Sun Jul 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Detection and Identification of Dental Caries Using Segmentation Techniques
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Dental caries, also named tooth decay, is a major issue for oral health and is caused by bacteria in dental plaque. Detecting caries early on is essential for preventing further damage. Because caries are often small, they can lead to unnecessary treatments or missed diagnoses. This study tackles the challenge of spotting dental caries using color image analysis. We tested both traditional methods—like Quickshift, Simple Linear Iterative Clustering (SLIC) superpixels, and k-means clustering—combined in the Multi-Step Segmentation with K-Means (MSS-KM) approach, as well as a more advanced deep learning method using YOLOv12 for segmentation. The evaluation of the performance of these methods based on accuracy, precision, recall, mean a

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Publication Date
Sun Jul 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Study on The Efficiency of Zinc Oxide Solid-State Solar Cells Using Organic Dyes Based on Indolene D102 Dye
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In this work, two carrier concentrations with dye D102 were used in a dye-sensitized solar cell to perform a comparative evaluation of the efficiency and influence on the study of key parameters affecting the device performance. To achieve this goal, the cell transfer power, current, current density and fill factor were calculated to estimate the power conversion efficiency (PCE) of DSSCs. Electrons move from the excited state of indolene D02 to the conduction band of ZnO to produce current for DSSCs through the assumed energy levels of donor indolene and acceptor ZnO in the hetero junction device to be continuous. The effect of carrier concentration and coupling strength on the improvement of the contact efficiency of D102 hetero juncti

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Publication Date
Sun Apr 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Estimate the parameters of Exponential-Rayleigh distribution, by using Bayesian method
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In this paper, point estimation method for parameters α and λ of the parameters of the Exponential-Rayleigh distribution have been estimated by the use of a simulation technique by using two Bayesian estimation methods; the first Bayesian method of estimation consists of Lindely approximation estimation method and the second Bayesian estimation method consists Tierney and kadane approximation estimation method to estimate all the unknown parameters (α,λ) of Exponential-Rayleigh distribution. Comparisons between these two methods were made by employing mean squares error criterion. Applying a simulation technique with different sample sizes, these methods are being compared.

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Publication Date
Sun Apr 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
New lifetime Shanker Weibull distribution: Structure and Properties
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This paper introduces a new model with two parameters titled “Shanker Weibull distribution". This distribution is obtained by merging the Shanker distribution with a scale of one parameter and the Weibull distribution with a shape parameter. First, we present the mathematical structure of the new distribution, which depends on the survival function for each of the Shanker and Weibull distributions. The statistical functions of this new distribution are presented, such as the cumulative, probability density, hazard and survival functions. In addition, we discuss the behavior of the probability density function and the hazard function by mxamining their shape. We also present the statistical properties of this distribution, which include

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Publication Date
Sun Apr 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Fixed point results and application for cyclic contractive maps in b-metric spaces
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One of the generalizations of the usual metric function is b-metric, which allows the researchers a wider aria to derive many results and applications regarding the fixed point theory.  This aim of the article is to advance new three fixed point principles in complete b-metric space  instance  is continuous function in two variables. Here, there are three directions to prove existence and uniqueness of fixed point. First, deriving a result in sense of Branciari’s theorem by combining integral contractive conditions with the idea of cyclic map. Second, applying the notion of cyclic representation regarding maps satisfying general weak conditions including an altering distance function to simulate the cont

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Publication Date
Sun Jul 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Some Oscillatory Results of Nonlinear Neutral Differential Equation
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In the last decades, functional differential equations have attracted the attention of many researchers; they were interested in the theory and its applications. The most common differential equations of functional type are advanced, neutral, and delay DEs. The theory of oscillatory DEs with retarded arguments has a paramount effect on the qualitative properties of DEs. It is essential to deduce conditions for oscillatory and non-oscillatory solutions. The objective of this paper is to obtain oscillatory conditions for differential equations with retarded arguments. So, the oscillatory behavior has been considered in the nonlinear differential equations (DEs) of neutral type with three delays. Some important conditions of all functions h

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Publication Date
Sun Jul 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Emerging Role of Microtubule-Associated Protein 2 as a Prognostic Factor for Renal Dysfunction
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     Chronic kidney disease (CKD) is a severe medical disorder manifested by a decline in kidney function over an extended period. This leads to the accumulation of toxins and the gradual inability to remove excess waste and fluids from the body. Microtubule-associated protein 2 (MAP2) is part of a protein family that regulates microtubule structure and cellular metabolism. This study aims to analyze the effectiveness of these parameters in evaluating CKD and its associated mechanisms in Iraqi patients. The study was conducted from December 2023 to May 2024. Ninety subjects enrolled in this study: 60 patients with CKD who attended the Baghdad Teaching Hospital/Medical City/ Dialysis Unit in Baghdad, Iraq. Additionally, 30 healthy sub

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Publication Date
Sun Apr 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Spectrophotometric Investigations for Simultaneous Analysis of Certain Antibacterial: A Brief Review
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     Antibacterial substances belong to a group of compounds that attack dangerous microorganisms. Therefore, killing bacteria or reducing their metabolic activity will lessen their adverse effects on a biological system. They originated from either synthetic materials, microbes, or mold. Many of these medications treat the gram-negative bacteria from the critical precedence group, such as Pseudomonas, carbapenem-resistant Acinetobacter, and Enterobacterales. This study aims to investigate the simultaneous analysis of specific antibacterial spectrophotometrically. The WHO maintains this list of priority infections with antibiotic resistance. Drug combinations in single dosage forms are becoming increasingly popular in the pharmaceuti

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Publication Date
Mon Apr 20 2020
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Analytical Study of Some Lightest Nuclei H, He, Li and Be
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     In the present study, the properties of the light elements, namely, H, He, Li, and Be, have been reviewed. Specifically, the nuclear decay of these nuclei has been reviewed. The mystery of the nuclear decay and potential is behind this work. The role of neutron has been investigated. The N/Z ratio has also been investigated in the study to relate the nuclear decay with the ratio. A new formula for nuclear potential has been suggested in the present study. This formula can describe the binding energy potential and the decayed particle energy depending on the N/Z ratio.

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Publication Date
Sun Jul 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Analysis of the Electrical Conductivity Mechanisms and Energy Density of States in Ternary Chalcogenide Alloy S<sub>60</sub>-Se<sub>40-X</sub>-Pb<sub>X</sub>
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We studied in this investigation the changes of the continuous conductivity of the electricity (σd.c) due to substituting part of Selenium with Lead in an S60-Se40-X-PbX alloy at weight ratios x = 0, 10, 20, and 30. Our investigation includes an examination of σd.c. mechanisms in chalcogenide semiconductors and governing the equations of the continuous D.C. electrical conductivity, and the application of these measured characteristics of S60-Se40-X-PbX glasses to assess Lead's impact on extended, local, and Fermi energy state densities. Some procedures were applied to the materials, such as mixing, grinding, heating in quartz ampoules, placing them

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Publication Date
Sun Apr 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
The Local Bifurcation of Food web Prey-Predator Model involving fear and anti-Predator behavior
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     In this paper, the conditions under which the occurrence of the local bifurcation (such as saddle-node (SN), transcritical (TC), and pitchfork (PT)) of all stable points of a food web model have been investigated. Fear and anti-predator responses involving the Holling-type IV and Growly-Martin functional responses have been found. It has been shown that there are transcritical and pitchfork bifurcations near  H3, H4, and H as well as a saddle-node bifurcation close to the positive equilibrium point. In addition, there is a saddle-node bifurcation in close to the positive equilibrium point. These divergences have materialised into existence. In conclusion, To prove that the analytical

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Publication Date
Sun Jul 20 2025
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Variable Viscosity Impact on Peristaltic Transport of Hybrid Nanomaterial in Tapered Channel
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This present study focuses on the analysis of peristaltic transport involving hybrid nanomaterial fluid through a tapered channel. Peristalsis of hybrid nanomaterial with variable viscosity is studied here. Thermal heat and velocity  with no-slip conditions are considered in the investigation. In order to simplify governing equations small Reynolds number and large wavelength assumptions are used, the exact solution for formulation of stream function , axial velocity and temperature are determined based on the perturbationechnique . In the present study, water is used as a head liquid while nanoparticle contains polystyrene and grapheme oxid. Additionally, main purpose is to explain impacts of  various physical parame

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Publication Date
Thu Mar 09 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Histological Study of The Cerebellum In Adult Quail Coturnix coturnix (Linnaeus, 1858)
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 A histological study was conducted to examine the structure of Cerebellum in Coturnix coturnix (Linnaeus). The results showed that the cerebellum is a portion of the Rhombencephalon and Metencephalon lying behind the cerebrum, the surface of the cerebellum contains deep folds and appears spherical in its shape. It represented the dorsal side of metencephalon and surrounded the roof of IV ventricle.          The cerebellum consists of three parts spino cerebellum, cerebro cerebelluum and vestibulo cerebellum; and three lobes anterior lobe, posterior lobe and flocculonodular lobe. The corpus cerebellum (Vermis) consists of nine folds called cerebellar-folia (IX-I) and separated from each other by sulci. &nbsp

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Publication Date
Mon Apr 20 2020
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Spectrophotometric Method for the Estimation of Ceftriaxone in Pure Form and Pharmaceuticals
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Ceftriaxone sodium were one of the widely antibacterial drugs used. Azo dye derivatization of diazonium salt that formed via the reaction between ceftriaxone with hydrochloric acid and sodium nitrite was developed for the on-research drug analysis then coupling with each one 2,5-dimethylphenol (2,5-DMP) and 4-tertbutylphenol (4-TBP) respectively in the alkaline media. The developed diazonium coupling methods include an optimization study. The results show a limit of detection and limit of quantification 0.482, 0.284 µg/mL, and 1.607, 0.945 µg/mL using 2,5-DMP and 4-TBP reagents respectively. Moreover, the recovery % obtained was 100.89%, and 103.37% at linear concentration range 3.0 – 50, and 10 – 30 µg/mL, with mo

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Publication Date
Mon Apr 20 2020
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
A Review: Saccharin Discovery, Synthesis, and Applications
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    Saccharin is firstly synthesized in 1879. It is a very well-known as an inexpensive substitute for sugar as it is a non-caloric sweetener. The article shows the properties, use, metabolism and various synthesis and reactions of saccharine. Moreover, the toxicological reports explain that saccharin is mostly responsible for the bladder tumors observed in the male rats, the relationship between the consumption of saccharin and bladder cancer is afforded by epidemiological studies.  The benefit-risk evaluation for saccharin is hardly to indicate. Saccharin is a sugar substitute, frequently used either in food industry, or in pharmaceutical formulations and even in tobacco products. The chemistry of saccharin is inter

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