The present study focuses on creating and engineering novel compounds based on five established medications: Sulfamethoxazole, Ampicillin, Cefotaxime, Sulfamethazine, and Trimethoprim. The research involves incorporating a biologically active component, specifically the 3,4-dimethyl maleimidyl sulfonamide group, into these drug molecules to produce the target compounds. Many steps were performed on this target; the first one involved a reaction between 3,4-dimethyl maleic anhydride and aniline to produce compound (1) N-phenyl-3,4-dimethyl maleimide which reacts with chlorosulfonic acid in the second step producing compound (2) 4-[N-(3՝,4՝-dimethyl maleimidyl)phenyl sulfonyl chloride. The third step involved compound (2) reaction with the selected drugs, producing the target- developed compounds (3-7). The newly synthesized compounds were tested for their antibacterial and antifungal activities. Results showed they exhibit high levels of activity against both bacteria and fungi.
Design, Synthesis, and Antimicrobial Activity Evaluation of New Developed Compounds via Introducing of 3, 4-Dimethyl Maleimidyl Sulfonamide Moiety
Drug compounds
3
4-dimethyl maleic anhydride
N-phenyl-3
4 dimethyl maleimide
3
4 dimethyl maleimidyl sulfonamide moiety